Linked Life Data

16426643

Source:http://linkedlifedata.com/resource/pubmed/id/16426643

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
23
pubmed:dateCreated
2006-4-24
pubmed:abstractText
Roles of transforming growth factor-beta (TGF-beta) receptor types I (TbetaRI) and II (TbetaRII) during the estrous cycle and implantation of rodents are currently unclear. In the present study, the spatial and temporal expressions of TbetaRI and TbetaRII in rat endometrium during the estrous cycle, pre-, and peri-implantation were examined using in situ hybridization and semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR). With in situ hybridization, TbetaRI and TbetaRII were expressed at weak levels in rat endometrium during the estrous cycle. During pre-implantation, both receptors were expressed in the luminal epithelium and glandular epithelium on Days 0.5 and 1.5 of pregnancy, but were down-regulated on Days 2.5 and 3.5. During peri-implantation, both TGF-beta receptors were localized in the luminal epithelium and subepithelial stroma to facilitate attachment reaction and trophoblast invasion. They were highly expressed on Day 4.5, whereas were down-regulated on Days 5.5 and 6.5. Semi-quantitative RT-PCR analysis confirmed the data obtained by in situ hybridization. These results suggest that during pre-implantation, both TGF-beta receptors are functional in the proliferation of endometrial epithelial cells. During peri-implantation, both TGF-beta receptors play important roles during the onset of the uterine receptivity and the attachment reaction. TGF-beta signaling is down-regulated when trophoblast invasion begins.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0024-3205
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
78
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2669-75
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:16426643-Activin Receptors, Type I, pubmed-meshheading:16426643-Animals, pubmed-meshheading:16426643-Cell Proliferation, pubmed-meshheading:16426643-Embryo Implantation, pubmed-meshheading:16426643-Endometrium, pubmed-meshheading:16426643-Estrous Cycle, pubmed-meshheading:16426643-Female, pubmed-meshheading:16426643-Gene Expression, pubmed-meshheading:16426643-Gestational Age, pubmed-meshheading:16426643-In Situ Hybridization, pubmed-meshheading:16426643-Pregnancy, pubmed-meshheading:16426643-Protein-Serine-Threonine Kinases, pubmed-meshheading:16426643-RNA, Messenger, pubmed-meshheading:16426643-Rats, pubmed-meshheading:16426643-Rats, Sprague-Dawley, pubmed-meshheading:16426643-Receptors, Transforming Growth Factor beta, pubmed-meshheading:16426643-Reverse Transcriptase Polymerase Chain Reaction
pubmed:year
2006
pubmed:articleTitle
Gene expression of transforming growth factor-beta receptors types I and II in rat endometrium during the estrous cycle and early pregnancy.
pubmed:affiliation
State Key Laboratory of Reproductive Biology, Institute of Zoology, the Chinese Academy of Sciences, 25 Bei Si Huan Xi Lu, Haidian District, Beijing 100080, PR China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't