Source:http://linkedlifedata.com/resource/pubmed/id/16426579
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2006-1-31
|
| pubmed:abstractText |
With the aid of microarray and PCR analysis, this investigation sought expression profiles of BDNF-regulated genes in cultured mouse cerebellar granule cells and addressed their relevance to gene regulation in developing granule cells in vivo. Many of the BDNF-upregulated and downregulated genes identified were upregulated and downregulated, respectively, during cerebellar development. This developmental change was, at least partly, prevented in the TrkB receptor-deficient cerebellum. The BDNF-upregulated genes were distributed in either postmigratory or both premigratory and postmigratory granule cells at postnatal day 8 (P8) and were still present in mature granule cells at P21. In contrast, the BDNF-downregulated genes were predominantly expressed in premigratory granule cells at P8 and disappeared at P21. Furthermore, many of the BDNF-upregulated gene products are implicated in signaling cascades of N-methyl-D-aspartate receptors and MAP kinase. The results indicate that BDNF signaling plays a pivotal role in promoting gene expression in granule cell development and maturation.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0006-291X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
10
|
| pubmed:volume |
341
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
304-9
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:16426579-Animals,
pubmed-meshheading:16426579-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:16426579-Cells, Cultured,
pubmed-meshheading:16426579-Cerebellum,
pubmed-meshheading:16426579-Down-Regulation,
pubmed-meshheading:16426579-Gene Expression Regulation,
pubmed-meshheading:16426579-Gene Expression Regulation, Developmental,
pubmed-meshheading:16426579-In Situ Hybridization,
pubmed-meshheading:16426579-Mice,
pubmed-meshheading:16426579-Mice, Inbred ICR,
pubmed-meshheading:16426579-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:16426579-Polymerase Chain Reaction,
pubmed-meshheading:16426579-RNA,
pubmed-meshheading:16426579-Receptor, trkB,
pubmed-meshheading:16426579-Signal Transduction,
pubmed-meshheading:16426579-Time Factors,
pubmed-meshheading:16426579-Up-Regulation
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Expression profile of BDNF-responsive genes during cerebellar granule cell development.
|
| pubmed:affiliation |
Department of Molecular and Systems Biology, Graduate School of Biostudies, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|