Linked Life Data

16426489

Source:http://linkedlifedata.com/resource/pubmed/id/16426489

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2006-1-23
pubmed:abstractText
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by anti-nuclear autoantibodies that cause damage to multiple organs and tissues. Intrinsic defects have been demonstrated in the lymphoid and myeloid cellular compartments, including T cells. Lupus susceptibility is mediated through the interplay of a large number of genes, most of which are still unidentified. Most of the genetic studies in both human patients and mouse models have addressed lupus susceptibility as a whole. More recently however, more attention has been paid to the inheritance of specific lupus-associated phenotypes. In this review, we summarized our results obtained with the Sle1 locus in the NZM2410 mouse model, which mediates the generation of anti-histone autoreactive T cells. Sle1, which is constituted of multiple genes, is the only known genomic region that is sufficient for the generation of autoreactive T cells. The identification of the corresponding genes will constitute a landmark for our understanding of the mechanisms of autoimmunity. Our results are discussed in the context of candidate genes and the role of T cells in systemic autoimmunity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1672-7681
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
403-9
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Genetics of T cell defects in lupus.
pubmed:affiliation
Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Fl, 32610, USA.
pubmed:publicationType
Journal Article, Review