Source:http://linkedlifedata.com/resource/pubmed/id/16424179
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2006-1-20
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| pubmed:abstractText |
X-linked lymphoproliferative disease (XLP) is a severe immunodeficiency associated with a marked reduction in circulating memory B cells. Our investigation of the B cell compartment of XLP patients revealed an increase in the frequency of a population of B cells distinct from those previously defined. This population displayed increased expression of CD10, CD24, and CD38, indicating that it could consist of circulating immature/transitional B cells. Supporting this possibility, CD10+CD24highCD38high B cells displayed other immature characteristics, including unmutated Ig V genes and elevated levels of surface IgM; they also lacked expression of Bcl-2 and a panel of activation molecules. The capacity of CD24highCD38high B cells to proliferate, secrete Ig, and migrate in vitro was greatly reduced compared with mature B cell populations. Moreover, CD24highCD38high B cells were increased in the peripheral blood of neonates, patients with common variable immunodeficiency, and patients recovering from hemopoietic stem cell transplant. Thus, an expansion of functionally immature B cells may contribute to the humoral immunodeficient state that is characteristic of neonates, as well as patients with XLP or common variable immunodeficiency, and those recovering from a stem cell transplant. Further investigation of transitional B cells will improve our understanding of human B cell development and how alterations to this process may precipitate immunodeficiency or autoimmunity.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD24,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD38,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD5,
http://linkedlifedata.com/resource/pubmed/chemical/CD38 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Variable Region,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0022-1767
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
176
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1506-16
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:16424179-Adolescent,
pubmed-meshheading:16424179-Adult,
pubmed-meshheading:16424179-Agammaglobulinemia,
pubmed-meshheading:16424179-Antigens, CD24,
pubmed-meshheading:16424179-Antigens, CD38,
pubmed-meshheading:16424179-Antigens, CD5,
pubmed-meshheading:16424179-B-Lymphocyte Subsets,
pubmed-meshheading:16424179-Cell Differentiation,
pubmed-meshheading:16424179-Cell Division,
pubmed-meshheading:16424179-Cell Movement,
pubmed-meshheading:16424179-Cell Survival,
pubmed-meshheading:16424179-Cells, Cultured,
pubmed-meshheading:16424179-Child,
pubmed-meshheading:16424179-Fetal Blood,
pubmed-meshheading:16424179-Humans,
pubmed-meshheading:16424179-Immunoglobulin Variable Region,
pubmed-meshheading:16424179-Lymphoproliferative Disorders,
pubmed-meshheading:16424179-Membrane Glycoproteins,
pubmed-meshheading:16424179-Middle Aged
|
| pubmed:year |
2006
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| pubmed:articleTitle |
Expansion of functionally immature transitional B cells is associated with human-immunodeficient states characterized by impaired humoral immunity.
|
| pubmed:affiliation |
Centenary Institute of Cancer Medicine and Cell Biology, New South Wales, Australia.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|