Linked Life Data

16424059

Source:http://linkedlifedata.com/resource/pubmed/id/16424059

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-1-20
pubmed:abstractText
S100P, an EF-hand calcium-binding protein, has been reported to be associated with the progression of many types of cancers. Transfection of an expression vector for S100P into a benign, nonmetastatic rat mammary cell line causes a 4- to 6-fold increase in its level in all four transformant cell clones. When the resultant transformant cell lines are introduced in turn into the mammary fat pads of syngeneic Furth-Wistar rats, there is a significant 3-fold increase in local muscle invasion and a significant induction of metastasis in 64% to 75% of tumor-bearing animals. In a group of 303 breast cancer patients followed for up to 20 years, antibodies to S100P immunocytochemically stain 161 primary tumors. Survival of patients with S100P-positive carcinomas is significantly worse by about 7-fold than for those with negatively stained carcinomas. There is also a significant association between the class level of immunocytochemical staining of the carcinoma cells and decreased patient survival. Positive staining for S100P is significantly associated with that for two other metastasis-inducing proteins, S100A4 and osteopontin. Patients with tumors that stained positively for both S100P and S100A4 have a significantly reduced survival of 1.1% over patients with either S100 protein alone. Multivariate regression analysis identifies S100P, S100A4, and osteopontin as the most significant independent indicators of death in this group of patients. These results suggest that stratification of patients into groups according to expression of multiple metastasis-inducing proteins may lead to a more accurate prediction of patient survival.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1199-207
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16424059-Adult, pubmed-meshheading:16424059-Aged, pubmed-meshheading:16424059-Aged, 80 and over, pubmed-meshheading:16424059-Animals, pubmed-meshheading:16424059-Antibody Formation, pubmed-meshheading:16424059-Breast Neoplasms, pubmed-meshheading:16424059-Calcium-Binding Proteins, pubmed-meshheading:16424059-Carcinoma, pubmed-meshheading:16424059-Female, pubmed-meshheading:16424059-Follow-Up Studies, pubmed-meshheading:16424059-Humans, pubmed-meshheading:16424059-Immunohistochemistry, pubmed-meshheading:16424059-Mammary Neoplasms, Animal, pubmed-meshheading:16424059-Middle Aged, pubmed-meshheading:16424059-Multivariate Analysis, pubmed-meshheading:16424059-Neoplasm Invasiveness, pubmed-meshheading:16424059-Neoplasm Metastasis, pubmed-meshheading:16424059-Neoplasm Proteins, pubmed-meshheading:16424059-Osteopontin, pubmed-meshheading:16424059-Prognosis, pubmed-meshheading:16424059-Rats, pubmed-meshheading:16424059-Rats, Wistar, pubmed-meshheading:16424059-Risk Assessment, pubmed-meshheading:16424059-S100 Proteins, pubmed-meshheading:16424059-Sialoglycoproteins, pubmed-meshheading:16424059-Survival Analysis, pubmed-meshheading:16424059-Transfection, pubmed-meshheading:16424059-Tumor Cells, Cultured
pubmed:year
2006
pubmed:articleTitle
Induction of metastasis by S100P in a rat mammary model and its association with poor survival of breast cancer patients.
pubmed:affiliation
Cancer and Polio Research Fund Laboratories, School of Biological Sciences, University of Liverpool, Liverpool L69 3BX, United Kingdom. wangg@liv.ac.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't