pubmed-article:16424058 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:16424058 | lifeskim:mentions | umls-concept:C0281361 | lld:lifeskim |
pubmed-article:16424058 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
pubmed-article:16424058 | lifeskim:mentions | umls-concept:C0009368 | lld:lifeskim |
pubmed-article:16424058 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
pubmed-article:16424058 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
pubmed-article:16424058 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:16424058 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
pubmed-article:16424058 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
pubmed-article:16424058 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
pubmed-article:16424058 | pubmed:issue | 2 | lld:pubmed |
pubmed-article:16424058 | pubmed:dateCreated | 2006-1-20 | lld:pubmed |
pubmed-article:16424058 | pubmed:abstractText | The activity of growth factors is crucial for tumor progression. We previously characterized a secreted fibroblast growth factor-binding protein (FGF-BP1) as a chaperone molecule, which enhances the biological functions of FGFs by releasing FGFs from the extracellular matrix. Here, we characterize the frequency and pattern of FGF-BP1 expression during the malignant progression of pancreas and colorectal carcinoma. For this, we generated monoclonal antibodies that detect FGF-BP1 protein in formalin-fixed, paraffin-embedded tissues and applied in situ hybridization to detect FGF-BP1 mRNA in adjacent tissue sections. FGF-BP1 protein and mRNA were found up-regulated (>70% positive) in parallel (r = 0.70, P < 0.0001) in colon adenoma (n = 9) as well as primary (n = 46) and metastatic (n = 71) colorectal cancers relative to normal colon epithelia (all P < 0.0001, versus normal). Similarly, pancreatitis (n = 17), pancreatic intraepithelial neoplasia (n = 80), and pancreatic adenocarcinoma (n = 67) showed a significant up-regulation of FGF-BP1 compared with normal pancreas (n = 42; all P < 0.0001, relative to normal). Furthermore, the biological activity of FGF-BP1 is neutralized by one of the antibodies, suggesting the potential for antibody-based therapeutic targeting. We propose that the up-regulation of the secreted FGF-BP1 protein during initiation of pancreas and colon neoplasia could make this protein a possible serum marker indicating the presence of high-risk premalignant lesions. | lld:pubmed |
pubmed-article:16424058 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:16424058 | pubmed:language | eng | lld:pubmed |
pubmed-article:16424058 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:16424058 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:16424058 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:16424058 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:16424058 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:16424058 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:16424058 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:16424058 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:16424058 | pubmed:month | Jan | lld:pubmed |
pubmed-article:16424058 | pubmed:issn | 0008-5472 | lld:pubmed |
pubmed-article:16424058 | pubmed:author | pubmed-author:WellsteinAnto... | lld:pubmed |
pubmed-article:16424058 | pubmed:author | pubmed-author:MaitraAnirban... | lld:pubmed |
pubmed-article:16424058 | pubmed:author | pubmed-author:BowdenEmma... | lld:pubmed |
pubmed-article:16424058 | pubmed:author | pubmed-author:HenkeRalf TRT | lld:pubmed |
pubmed-article:16424058 | pubmed:author | pubmed-author:TassiElenaE | lld:pubmed |
pubmed-article:16424058 | pubmed:author | pubmed-author:SwiftMatthew... | lld:pubmed |
pubmed-article:16424058 | pubmed:author | pubmed-author:KodackDavid... | lld:pubmed |
pubmed-article:16424058 | pubmed:author | pubmed-author:KuoAngera HAH | lld:pubmed |
pubmed-article:16424058 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:16424058 | pubmed:day | 15 | lld:pubmed |
pubmed-article:16424058 | pubmed:volume | 66 | lld:pubmed |
pubmed-article:16424058 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:16424058 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:16424058 | pubmed:pagination | 1191-8 | lld:pubmed |
pubmed-article:16424058 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
pubmed-article:16424058 | pubmed:meshHeading | pubmed-meshheading:16424058... | lld:pubmed |
pubmed-article:16424058 | pubmed:meshHeading | pubmed-meshheading:16424058... | lld:pubmed |
pubmed-article:16424058 | pubmed:meshHeading | pubmed-meshheading:16424058... | lld:pubmed |
pubmed-article:16424058 | pubmed:meshHeading | pubmed-meshheading:16424058... | lld:pubmed |
pubmed-article:16424058 | pubmed:meshHeading | pubmed-meshheading:16424058... | lld:pubmed |
pubmed-article:16424058 | pubmed:meshHeading | pubmed-meshheading:16424058... | lld:pubmed |
pubmed-article:16424058 | pubmed:meshHeading | pubmed-meshheading:16424058... | lld:pubmed |
pubmed-article:16424058 | pubmed:meshHeading | pubmed-meshheading:16424058... | lld:pubmed |
pubmed-article:16424058 | pubmed:meshHeading | pubmed-meshheading:16424058... | lld:pubmed |
pubmed-article:16424058 | pubmed:meshHeading | pubmed-meshheading:16424058... | lld:pubmed |
pubmed-article:16424058 | pubmed:meshHeading | pubmed-meshheading:16424058... | lld:pubmed |
pubmed-article:16424058 | pubmed:meshHeading | pubmed-meshheading:16424058... | lld:pubmed |
pubmed-article:16424058 | pubmed:meshHeading | pubmed-meshheading:16424058... | lld:pubmed |
pubmed-article:16424058 | pubmed:meshHeading | pubmed-meshheading:16424058... | lld:pubmed |
pubmed-article:16424058 | pubmed:meshHeading | pubmed-meshheading:16424058... | lld:pubmed |
pubmed-article:16424058 | pubmed:meshHeading | pubmed-meshheading:16424058... | lld:pubmed |
pubmed-article:16424058 | pubmed:year | 2006 | lld:pubmed |
pubmed-article:16424058 | pubmed:articleTitle | Expression of a fibroblast growth factor-binding protein during the development of adenocarcinoma of the pancreas and colon. | lld:pubmed |
pubmed-article:16424058 | pubmed:affiliation | Lombardi Cancer Center, Georgetown University, 3970 Reservoir Road, Washington, DC 20057, USA. | lld:pubmed |
pubmed-article:16424058 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:16424058 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
pubmed-article:16424058 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
entrez-gene:2260 | entrezgene:pubmed | pubmed-article:16424058 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16424058 | lld:entrezgene |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16424058 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16424058 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16424058 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16424058 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16424058 | lld:pubmed |