Source:http://linkedlifedata.com/resource/pubmed/id/16424049
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2006-1-20
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| pubmed:abstractText |
The accumulation of myeloid suppressor cells (MSCs) is associated with immune suppression in tumor-bearing mice and in cancer patients. The suppressive activity of MSC correlates with the expression of the myeloid markers Gr-1, CD115 (macrophage colony-stimulating factor receptor), and F4/80. Gr-1(+)CD115(+) MSCs, in addition to being able to suppress T-cell proliferation in vitro, can induce the development of Foxp3(+) T regulatory cells (Treg) in vivo, which are anergic and suppressive. Furthermore, the secretion of interleukin (IL)-10 and transforming growth factor-beta by Gr-1(+)CD115(+) MSCs was induced and enhanced, respectively, on IFN-gamma stimulation. The development of Treg requires antigen-associated activation of tumor-specific T cells, depends on the presence of IFN-gamma and IL-10, and is independent of the nitric oxide-mediated suppressive mechanism by MSC. Our data provide evidence that Gr-1(+)CD115(+) MSC can mediate the development of Treg in tumor-bearing mice and show a novel immune suppressive mechanism by which MSCs can suppress antitumor responses.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0008-5472
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
15
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| pubmed:volume |
66
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1123-31
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:16424049-Animals,
pubmed-meshheading:16424049-Cell Proliferation,
pubmed-meshheading:16424049-Clonal Anergy,
pubmed-meshheading:16424049-Colonic Neoplasms,
pubmed-meshheading:16424049-Cytokines,
pubmed-meshheading:16424049-Female,
pubmed-meshheading:16424049-Immunosuppression,
pubmed-meshheading:16424049-Lymphocyte Activation,
pubmed-meshheading:16424049-Male,
pubmed-meshheading:16424049-Mice,
pubmed-meshheading:16424049-Mice, Inbred BALB C,
pubmed-meshheading:16424049-Receptor, Macrophage Colony-Stimulating Factor,
pubmed-meshheading:16424049-Receptors, Chemokine,
pubmed-meshheading:16424049-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16424049-T-Lymphocytes,
pubmed-meshheading:16424049-T-Lymphocytes, Regulatory,
pubmed-meshheading:16424049-Transfection,
pubmed-meshheading:16424049-Tumor Cells, Cultured
|
| pubmed:year |
2006
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| pubmed:articleTitle |
Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host.
|
| pubmed:affiliation |
Departments of Gene and Cell Medicine and General Surgery, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|