Linked Life Data

16423883

Source:http://linkedlifedata.com/resource/pubmed/id/16423883

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2006-5-2
pubmed:abstractText
Members of the steroid receptor coactivator (SRC) family, which include SRC-1 (NcoA-1/p160), SRC-2(TIF2/GRIP1/NcoA-2) and SRC-3(pCIP/RAC3/ACTR/pCIP/ AIB1/TRAM1), are critical mediators of steroid receptor action. Gene ablation studies previously identified SRC-1 and SRC-2 as being involved in the control of energy homeostasis. A more precise identification of the molecular pathways regulated by these coactivators is crucial for understanding the role of steroid receptor coactivators in the control of energy homeostasis and obesity. A genomic approach using microarray analysis was employed to identify the subsets of genes that are altered in the livers of SRC-1-/-, SRC-2-/-, and SRC-3-/- mice. Microarray analysis demonstrates that gene expression changes are specific and nonoverlapping for each SRC member in the liver. The overall pattern of altered gene expressions in the SRC-1-/- mice was up-regulation, whereas SRC-2-/- mice showed an overall down-regulation. Several key regulatory enzymes of energy metabolism were significantly altered in the liver of SRC-2-/- mice, which are consistent with the prior observation that SRC-2-/- mice have increased energy expenditure. This study demonstrates that the molecular targets of SRC-2 regulation in the murine liver stimulate fatty acid degradation and glycolytic pathway, whereas fatty acid, cholesterol, and steroid biosynthetic pathways are down-regulated.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0888-8809
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1138-52
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:16423883-Animals, pubmed-meshheading:16423883-Cell Cycle, pubmed-meshheading:16423883-Energy Metabolism, pubmed-meshheading:16423883-Fatty Acids, pubmed-meshheading:16423883-Gene Expression Regulation, pubmed-meshheading:16423883-Genomics, pubmed-meshheading:16423883-Glycogen, pubmed-meshheading:16423883-Histone Acetyltransferases, pubmed-meshheading:16423883-Liver, pubmed-meshheading:16423883-Mice, pubmed-meshheading:16423883-Mice, Mutant Strains, pubmed-meshheading:16423883-Nuclear Receptor Coactivator 1, pubmed-meshheading:16423883-Nuclear Receptor Coactivator 2, pubmed-meshheading:16423883-Nuclear Receptor Coactivator 3, pubmed-meshheading:16423883-Oligonucleotide Array Sequence Analysis, pubmed-meshheading:16423883-Trans-Activators, pubmed-meshheading:16423883-Transcription Factors
pubmed:year
2006
pubmed:articleTitle
The genomic analysis of the impact of steroid receptor coactivators ablation on hepatic metabolism.
pubmed:affiliation
Department of Molecular and Cellular Biology, Microarray Core Facility, Baylor College of Medicine, Houston, Texas 77030, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural