Source:http://linkedlifedata.com/resource/pubmed/id/16421704
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2006-3-3
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| pubmed:abstractText |
Epithelioid hemangioendothelioma (EHE) of the lungs (syn.: intravascular bronchioloalveolar tumor/IVBAT) is a neoplasm with a vascular line of differentiation. This study provides a clinicopathological analysis of 11 cases of this tumor. There were 7 female and 4 male patients. Patients' age ranged from 33 to 83 years (mean: 49.8, median: 48 years) showing 2 peaks (third/fourth and sixth/eighth decades). The typical radiological appearance revealed multiple bilateral lung nodules from 0.5 to 2 cm. In 2 cases, a striking perivascular and intravascular growth pattern associated to pulmonary veins was evident. All tumors were characterized by epithelioid tumor cells with nests, cords and strands embedded in a sclerosing, hyaline matrix with alveolar, bronchiolar and vascular extension. Necrosis was identified in 8 tumors and ossification in 2 tumors. The mitotic index was below one mitosis in 10 HPF. By immunohistochemistry, all tumors were positive for CD 31, CD 34, and vimentin, 60% positive for factor VIII, and negative for pancytokeratin and calretinin. Follow-up was available for 8 patients with a range of 6 to 105 months (mean: 51.5 months, median: 52 months): 3 patients died (2 certainly from their tumors), 4 are alive disease-free, and one is alive with metastases. EHE of the lungs (IVBAT) represents an intermediate-grade, malignant, mesenchymal neoplasm with a characteristic histological appearance and immunohistochemical profile.
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| pubmed:language |
ger
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0172-8113
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
27
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
106-15
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| pubmed:meshHeading |
pubmed-meshheading:16421704-Adult,
pubmed-meshheading:16421704-Aged,
pubmed-meshheading:16421704-Aged, 80 and over,
pubmed-meshheading:16421704-Biopsy,
pubmed-meshheading:16421704-Cell Transformation, Neoplastic,
pubmed-meshheading:16421704-Endothelium, Vascular,
pubmed-meshheading:16421704-Female,
pubmed-meshheading:16421704-Hemangioendothelioma, Epithelioid,
pubmed-meshheading:16421704-Humans,
pubmed-meshheading:16421704-Lung,
pubmed-meshheading:16421704-Lung Neoplasms,
pubmed-meshheading:16421704-Male,
pubmed-meshheading:16421704-Middle Aged,
pubmed-meshheading:16421704-Mitotic Index,
pubmed-meshheading:16421704-Necrosis,
pubmed-meshheading:16421704-Neoplasm Invasiveness,
pubmed-meshheading:16421704-Neoplasms, Multiple Primary,
pubmed-meshheading:16421704-Ossification, Heterotopic,
pubmed-meshheading:16421704-Prognosis,
pubmed-meshheading:16421704-Pulmonary Veins,
pubmed-meshheading:16421704-Survival Analysis,
pubmed-meshheading:16421704-Tumor Markers, Biological
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| pubmed:year |
2006
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| pubmed:articleTitle |
[Epithelioid hemangioendothelioma of the lung (IVBAT)--clinicopathological and immunohistochemical analysis of 11 cases].
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| pubmed:affiliation |
Institut für Pathologie der Ruhr-Universität Bochum, Berufsgenossenschaftliche Kliniken Bergmannsheil.
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| pubmed:publicationType |
Journal Article,
English Abstract
|