Linked Life Data

16421590

Source:http://linkedlifedata.com/resource/pubmed/id/16421590

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2006-2-8
pubmed:abstractText
Patients who have no residual invasive cancer following neoadjuvant chemotherapy for breast carcinoma have a better overall survival than those with residual disease. Many classification systems assessing pathological response to neoadjuvant chemotherapy include residual ductal carcinoma in situ (DCIS) only in the definition of pathological complete response. The purpose of this study was to investigate whether patients with residual DCIS only have the same prognosis as those with no residual invasive or in situ disease. A retrospective analysis of a prospectively maintained database identified 435 patients, who received neoadjuvant chemotherapy for operable breast cancer between February 1985 and February 2003. Of these, 30 (7%; 95% CI 5-9%) had no residual invasive disease or DCIS and 20 (5%; CI 3-7%) had residual DCIS only. With a median follow-up of 61 months, there was no statistical difference in disease-free survival, 80% (95% CI 60-90%) in those with no residual invasive or in situ disease and 61% (95% CI 35-80%) in those with DCIS only (P=0.4). No significant difference in 5-year overall survival was observed, 93% (95% CI 75-98%) in those with no residual invasive or in situ disease and 82% (95% CI 52-94%) in those with DCIS only (P=0.3). Due to the small number of patients and limited number of events in each group, it is not possible to draw definitive conclusions from this study. Further analyses of other databases are required to confirm our finding of no difference in disease-free and overall survival between patients with residual DCIS and those with no invasive or in situ disease following neoadjuvant chemotherapy for breast cancer.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16421590-10080586, http://linkedlifedata.com/resource/pubmed/commentcorrection/16421590-11773300, http://linkedlifedata.com/resource/pubmed/commentcorrection/16421590-11953845, http://linkedlifedata.com/resource/pubmed/commentcorrection/16421590-14659147, http://linkedlifedata.com/resource/pubmed/commentcorrection/16421590-15197191, http://linkedlifedata.com/resource/pubmed/commentcorrection/16421590-7459811, http://linkedlifedata.com/resource/pubmed/commentcorrection/16421590-7884414, http://linkedlifedata.com/resource/pubmed/commentcorrection/16421590-831755, http://linkedlifedata.com/resource/pubmed/commentcorrection/16421590-8338056, http://linkedlifedata.com/resource/pubmed/commentcorrection/16421590-9215816, http://linkedlifedata.com/resource/pubmed/commentcorrection/16421590-9291806, http://linkedlifedata.com/resource/pubmed/commentcorrection/16421590-9440728, http://linkedlifedata.com/resource/pubmed/commentcorrection/16421590-9484820, http://linkedlifedata.com/resource/pubmed/commentcorrection/16421590-9689981, http://linkedlifedata.com/resource/pubmed/commentcorrection/16421590-9704717
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0007-0920
pubmed:author
pubmed:issnType
Print
pubmed:day
13
pubmed:volume
94
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
358-62
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Pathological complete response and residual DCIS following neoadjuvant chemotherapy for breast carcinoma.
pubmed:affiliation
Breast Unit, Royal Marsden NHS Trust, Fulham Road, London SW3 6JJ, UK, and Molecular and Cellular Pathology, School of Medicine, University of Queensland, Mayne Medical School, Herston, Australia.
pubmed:publicationType
Journal Article