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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-1-19
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pubmed:abstractText |
Plasma protein S (PS) is an essential anticoagulant that has activated protein C-independent, direct anticoagulant activity (PS-direct). It was reported that monomeric purified PS has poor PS-direct and that a subpopulation of multimeric purified PS has high PS-direct and high affinity for phospholipids. We independently examined the relative PS-direct and affinity for phospholipids of monomeric and multimeric PS and we obtained contrasting results.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1538-7933
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
385-91
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16420570-Anticoagulants,
pubmed-meshheading:16420570-Binding, Competitive,
pubmed-meshheading:16420570-Dimerization,
pubmed-meshheading:16420570-Factor Xa,
pubmed-meshheading:16420570-Histocompatibility Antigens,
pubmed-meshheading:16420570-Humans,
pubmed-meshheading:16420570-Ligands,
pubmed-meshheading:16420570-Phospholipids,
pubmed-meshheading:16420570-Protein S,
pubmed-meshheading:16420570-Protein Structure, Quaternary,
pubmed-meshheading:16420570-Recombinant Proteins,
pubmed-meshheading:16420570-Ultracentrifugation
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pubmed:year |
2006
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pubmed:articleTitle |
Protein S multimers and monomers each have direct anticoagulant activity.
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pubmed:affiliation |
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA. heeb@scripps.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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