Linked Life Data

16420169

Source:http://linkedlifedata.com/resource/pubmed/id/16420169

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2006-1-19
pubmed:abstractText
Five experiments examined the reinstatement of fear (freezing) produced by recent reexposure to a dangerous context. Rats were trained to fear a conditioned stimulus (CS) and a distinctive context with shock. The CS was then extinguished. A 2-min interval between reexposure to the dangerous context and presentation of the extinguished CS in a different context reinstated freezing when the CS was tested the next day. Propranolol (a beta-adrenergic antagonist) blocked reinstatement of extinguished fear without decreasing freezing to a nonextinguished CS. Administration of epinephrine (an adrenergic agonist) reinstated extinguished fear without reexposure to the dangerous context. The results suggest a role for beta-adrenergic activity elicited by exposure to a conditioned context in the reinstatement of extinguished fear.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0735-7044
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2006 APA, all rights reserved.
pubmed:issnType
Print
pubmed:volume
119
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1662-71
pubmed:dateRevised
2007-8-13
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Reinstatement of extinguished fear by beta-adrenergic arousal elicited by a conditioned context.
pubmed:affiliation
School of Psychology, University of New South Wales, Sydney, NSW, Australia. rmorris@uvm.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't