Linked Life Data

16418321

Source:http://linkedlifedata.com/resource/pubmed/id/16418321

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-4-14
pubmed:abstractText
Cystic fibrosis (CF) is caused by a defect in the CF transmembrane conductance regulator (CFTR) protein that functions as a chloride channel. Dysfunction of the CFTR protein results in salty sweat, pancreatic insufficiency, intestinal obstruction, male infertility, and severe pulmonary disease. Most of the morbidity and mortality of CF patients results from pulmonary complications. Differences in susceptibility to bacterial infection and variable degree of CF lung disease among CF patients remain unexplained. Many phenotypic expressions of the disease do not directly correlate with the type of mutation in the Cftr gene. Using a unique CF mouse model that mimics aspects of human CF lung disease, we analyzed the differential gene expression pattern between the normal lungs of wild-type mice (WT) and the affected lungs of CFTR knockout mice (KO). Using microarray analysis followed by quantitation of candidate gene mRNA and protein expression, we identified many interesting genes involved in the development of CF lung disease in mice. These findings point to distinct mechanisms of gene expression regulation between mice with CF and control mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1531-2267
pubmed:author
pubmed:issnType
Electronic
pubmed:day
13
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
179-93
pubmed:meshHeading
pubmed-meshheading:16418321-Animals, pubmed-meshheading:16418321-Cystic Fibrosis, pubmed-meshheading:16418321-Disease Models, Animal, pubmed-meshheading:16418321-Female, pubmed-meshheading:16418321-Gene Expression Regulation, pubmed-meshheading:16418321-Immunoglobulin G, pubmed-meshheading:16418321-Lung, pubmed-meshheading:16418321-Male, pubmed-meshheading:16418321-Matrix Metalloproteinase 9, pubmed-meshheading:16418321-Mice, pubmed-meshheading:16418321-Mice, Inbred CFTR, pubmed-meshheading:16418321-Oligonucleotide Array Sequence Analysis, pubmed-meshheading:16418321-Pneumonia, Bacterial, pubmed-meshheading:16418321-Pseudomonas Infections, pubmed-meshheading:16418321-RNA, Messenger, pubmed-meshheading:16418321-Reproducibility of Results, pubmed-meshheading:16418321-Secretory Leukocyte Peptidase Inhibitor
pubmed:year
2006
pubmed:articleTitle
Distinct pattern of lung gene expression in the Cftr-KO mice developing spontaneous lung disease compared with their littermate controls.
pubmed:affiliation
McGill University Health Center Research Institute, Montreal, Canada.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't