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rdf:type |
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lifeskim:mentions |
umls-concept:C0012854,
umls-concept:C0017337,
umls-concept:C0026882,
umls-concept:C0443343,
umls-concept:C0544886,
umls-concept:C0598034,
umls-concept:C0672152,
umls-concept:C0685938,
umls-concept:C0920269,
umls-concept:C1326912,
umls-concept:C1417250,
umls-concept:C1519302,
umls-concept:C1707391
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pubmed:dateCreated |
2008-3-11
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pubmed:abstractText |
The BRCA2 and MRE11 proteins participate in the repair of double-strand DNA breaks by homologous recombination. Germline BRCA2 mutations predispose to ovarian, breast and pancreatic cancer, while a germline MRE11 mutation is associated with an ataxia telangiectasia-like disorder. Somatic mutations of BRCA2 are rare in typical sporadic cancers. In tumors having microsatellite instability (MSI), somatic truncating mutations in a poly [A] tract of BRCA2 are reported on occasion.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16417627-10451700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16417627-10534775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16417627-10545425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16417627-10581236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16417627-10601558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16417627-10793087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16417627-11196167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16417627-11239455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16417627-11239456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16417627-11325855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16417627-11850399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16417627-11980631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16417627-12170779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16417627-12210079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16417627-12509276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16417627-12615714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16417627-12700658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16417627-15048091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16417627-15126332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16417627-15256444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16417627-15375219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16417627-15735671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16417627-7553647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16417627-7585632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16417627-8505985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16417627-8665505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16417627-8968085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16417627-9331106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16417627-9652743
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/BLID protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/BRCA2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/BRCA2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MRE11A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RAD51 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Rad51 Recombinase
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2156
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:16417627-Apoptosis Regulatory Proteins,
pubmed-meshheading:16417627-BRCA2 Protein,
pubmed-meshheading:16417627-Cell Line, Tumor,
pubmed-meshheading:16417627-Colorectal Neoplasms,
pubmed-meshheading:16417627-DNA Mismatch Repair,
pubmed-meshheading:16417627-DNA-Binding Proteins,
pubmed-meshheading:16417627-Frameshift Mutation,
pubmed-meshheading:16417627-Gastrointestinal Neoplasms,
pubmed-meshheading:16417627-Genes, BRCA2,
pubmed-meshheading:16417627-Humans,
pubmed-meshheading:16417627-Loss of Heterozygosity,
pubmed-meshheading:16417627-Microsatellite Instability,
pubmed-meshheading:16417627-Pancreatic Neoplasms,
pubmed-meshheading:16417627-Rad51 Recombinase,
pubmed-meshheading:16417627-Sequence Analysis, DNA
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pubmed:year |
2006
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pubmed:articleTitle |
Does tumorigenesis select for or against mutations of the DNA repair-associated genes BRCA2 and MRE11?: considerations from somatic mutations in microsatellite unstable (MSI) gastrointestinal cancers.
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pubmed:affiliation |
From the department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland. m.s.vanderheijden@amc.uva.nl
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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