Source:http://linkedlifedata.com/resource/pubmed/id/16416420
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2006-2-14
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pubmed:abstractText |
The beta-cell ATP-sensitive potassium channel is a key component of stimulus-secretion coupling in the pancreatic beta-cell. The channel couples metabolism to membrane electrical events, bringing about insulin secretion. Given the critical role of this channel in glucose homeostasis, it is not surprising that mutations in the genes encoding for the two essential subunits of the channel can result in both hypo- and hyperglycemia. The channel consists of four subunits of the inwardly rectifying potassium channel Kir6.2 and four subunits of the sulfonylurea receptor 1. It has been known for some time that loss of function mutations in KCNJ11, which encodes for Kir6.2, and ABCC8, which encodes for SUR1, can cause oversecretion of insulin and result in hyperinsulinemia (HI) of infancy; however, heterozygous activating mutations in KCNJ11 that result in the opposite phenotype of diabetes have recently been described. This review focuses on reported mutations in both genes, the spectrum of phenotypes, and the implications for treatment when patients are diagnosed with mutations in these genes.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Kir6.2 channel,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, Inwardly...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Drug,
http://linkedlifedata.com/resource/pubmed/chemical/sulfonylurea receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1098-1004
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pubmed:author | |
pubmed:copyrightInfo |
2006 Wiley-Liss, Inc.
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pubmed:issnType |
Electronic
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
220-31
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16416420-ATP-Binding Cassette Transporters,
pubmed-meshheading:16416420-Diabetes Mellitus,
pubmed-meshheading:16416420-Genetic Predisposition to Disease,
pubmed-meshheading:16416420-Humans,
pubmed-meshheading:16416420-Hyperinsulinism,
pubmed-meshheading:16416420-Insulin,
pubmed-meshheading:16416420-Insulin-Secreting Cells,
pubmed-meshheading:16416420-Models, Biological,
pubmed-meshheading:16416420-Mutation,
pubmed-meshheading:16416420-Phenotype,
pubmed-meshheading:16416420-Potassium Channels,
pubmed-meshheading:16416420-Potassium Channels, Inwardly Rectifying,
pubmed-meshheading:16416420-Receptors, Drug
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pubmed:year |
2006
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pubmed:articleTitle |
Mutations in the genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) in diabetes mellitus and hyperinsulinism.
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pubmed:affiliation |
Diabetes Research Laboratories, Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom. anna.gloyn@drl.ox.ac.uk
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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