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rdf:type |
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lifeskim:mentions |
umls-concept:C0001792,
umls-concept:C0017431,
umls-concept:C0030705,
umls-concept:C0059735,
umls-concept:C0149782,
umls-concept:C0205195,
umls-concept:C0681850,
umls-concept:C0919425,
umls-concept:C0919534,
umls-concept:C1550501,
umls-concept:C1706203,
umls-concept:C2349001,
umls-concept:C2697811
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|
pubmed:issue |
5
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pubmed:dateCreated |
2006-2-27
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|
pubmed:abstractText |
Polycyclic aromatic hydrocarbons are activated by cytochrome P450 1A1 (CYP1A1) and inactivated by glutathione S-transferase mu (GSTM1). Therefore, it is expected that a combination of proficient CYP1A1 genotype with deficient GSTM1 variant would result in particularly elevated lung cancer (LC) risk, especially for squamous cell carcinoma (SCC). This study was aimed to validate whether the CYP1A1-C (3801) (CYP1A1*2) allele has an unfavorable significance alone and/or in combination with the GSTM1 deficiency.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0171-5216
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pubmed:author |
pubmed-author:BelogubovaEvgeniya VEV,
pubmed-author:HansonKaido PKP,
pubmed-author:HirvonenAriA,
pubmed-author:ImyanitovEvgeny NEN,
pubmed-author:KarpovaMaria BMB,
pubmed-author:KoloskovAndrey VAV,
pubmed-author:KuchinskiyAlexandr PAP,
pubmed-author:KuliginaEkatherina ShESh,
pubmed-author:ShutkinVladimir AVA,
pubmed-author:SuvorovaIrina KIK,
pubmed-author:TogoAlexandr VAV,
pubmed-author:UlibinaYulia MYM
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pubmed:issnType |
Print
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pubmed:volume |
132
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
327-31
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pubmed:meshHeading |
pubmed-meshheading:16416283-Adolescent,
pubmed-meshheading:16416283-Adult,
pubmed-meshheading:16416283-Aged,
pubmed-meshheading:16416283-Aged, 80 and over,
pubmed-meshheading:16416283-Carcinoma, Squamous Cell,
pubmed-meshheading:16416283-Cytochrome P-450 CYP1A1,
pubmed-meshheading:16416283-Genetic Predisposition to Disease,
pubmed-meshheading:16416283-Genotype,
pubmed-meshheading:16416283-Glutathione Transferase,
pubmed-meshheading:16416283-Humans,
pubmed-meshheading:16416283-Lung Neoplasms,
pubmed-meshheading:16416283-Middle Aged,
pubmed-meshheading:16416283-Risk Factors
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pubmed:year |
2006
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|
pubmed:articleTitle |
Combined CYP1A1/GSTM1 at-risk genotypes are overrepresented in squamous cell lung carcinoma patients but underrepresented in elderly tumor-free subjects.
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pubmed:affiliation |
Group of Molecular Diagnostics, N.N. Petrov Institute of Oncology, Pesochny-2, 197758 St.-Petersburg, Russia.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
