|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2006-2-27
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
We have previously reported suggestive linkage of type 2 diabetes mellitus to chromosome 10q. We genotyped 228 microsatellite markers in Icelandic individuals with type 2 diabetes and controls throughout a 10.5-Mb interval on 10q. A microsatellite, DG10S478, within intron 3 of the transcription factor 7-like 2 gene (TCF7L2; formerly TCF4) was associated with type 2 diabetes (P = 2.1 x 10(-9)). This was replicated in a Danish cohort (P = 4.8 x 10(-3)) and in a US cohort (P = 3.3 x 10(-9)). Compared with non-carriers, heterozygous and homozygous carriers of the at-risk alleles (38% and 7% of the population, respectively) have relative risks of 1.45 and 2.41. This corresponds to a population attributable risk of 21%. The TCF7L2 gene product is a high mobility group box-containing transcription factor previously implicated in blood glucose homeostasis. It is thought to act through regulation of proglucagon gene expression in enteroendocrine cells via the Wnt signaling pathway.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
1061-4036
|
|
pubmed:author |
pubmed-author:BaggerYuY,
pubmed-author:BenediktssonRafnR,
pubmed-author:ChristiansenClausC,
pubmed-author:EmilssonValurV,
pubmed-author:GrantStruan F ASF,
pubmed-author:GudmundsdottirThorunnT,
pubmed-author:GudnasonVilmundurV,
pubmed-author:GulcherJeffrey RJR,
pubmed-author:GylfasonArnaldurA,
pubmed-author:HelgadottirAnnaA,
pubmed-author:HelgasonAgnarA,
pubmed-author:JonsdottirThorbjorgT,
pubmed-author:KongAugustineA,
pubmed-author:MagnussonKristinn PKP,
pubmed-author:ManolescuAndreiA,
pubmed-author:PalsdottirEbbaE,
pubmed-author:RaderDaniel JDJ,
pubmed-author:ReillyMuredach PMP,
pubmed-author:ReynisdottirIngaI,
pubmed-author:SaemundsdottirJonaJ,
pubmed-author:SainzJesusJ,
pubmed-author:SigurdssonGunnarG,
pubmed-author:StefanssonHreinnH,
pubmed-author:StefanssonKariK,
pubmed-author:StyrkarsdottirUnnurU,
pubmed-author:ThorleifssonGudmarG,
pubmed-author:ThorsteinsdottirUnnurU,
pubmed-author:WaltersG BragiGB,
pubmed-author:WilenskyRobert LRL
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
38
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
320-3
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:16415884-Chromosome Mapping,
pubmed-meshheading:16415884-Chromosomes, Human, Pair 10,
pubmed-meshheading:16415884-Cohort Studies,
pubmed-meshheading:16415884-Denmark,
pubmed-meshheading:16415884-Diabetes Mellitus, Type 2,
pubmed-meshheading:16415884-Gene Frequency,
pubmed-meshheading:16415884-Genetic Predisposition to Disease,
pubmed-meshheading:16415884-Heterozygote Detection,
pubmed-meshheading:16415884-Humans,
pubmed-meshheading:16415884-Introns,
pubmed-meshheading:16415884-Microsatellite Repeats,
pubmed-meshheading:16415884-Molecular Sequence Data,
pubmed-meshheading:16415884-Reference Values,
pubmed-meshheading:16415884-TCF Transcription Factors,
pubmed-meshheading:16415884-Transcription Factor 7-Like 2 Protein
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes.
|
|
pubmed:affiliation |
deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland. struan.grant@decode.is
|
|
pubmed:publicationType |
Journal Article
|
