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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2006-1-17
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pubmed:abstractText |
Polyadenylation of B19 pre-mRNAs at the major internal site, (pA)p1, is programmed by the nonconsensus core cleavage and polyadenylation specificity factor-binding hexanucleotide AUUAAA. Efficient use of this element requires both downstream and upstream cis-acting elements and is further influenced by an adjacent AAUAAC motif. The primary hexanucleotide element must be nonconsensus to allow efficient readthrough of P6-generated pre-mRNAs into the capsid-coding region. An additional cleavage and polyadenylation site, (pA)p2, 296 nucleotides downstream of (pA)p1 was shown to be used following both B19 infection and transfection of a genomic clone. RNAs polyadenylated at (pA)p2 comprise approximately 10% of B19 RNAs that are polyadenylated internally.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16415037-10357856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16415037-11462027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16415037-12438569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16415037-1385833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16415037-14762186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16415037-14972543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16415037-15452211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16415037-15542645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16415037-1592259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16415037-16103154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16415037-1825251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16415037-2053277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16415037-2800343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16415037-2843669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16415037-3599180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16415037-8337823
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1604-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16415037-Alternative Splicing,
pubmed-meshheading:16415037-Animals,
pubmed-meshheading:16415037-Base Sequence,
pubmed-meshheading:16415037-Binding Sites,
pubmed-meshheading:16415037-COS Cells,
pubmed-meshheading:16415037-Cercopithecus aethiops,
pubmed-meshheading:16415037-Humans,
pubmed-meshheading:16415037-Molecular Sequence Data,
pubmed-meshheading:16415037-Parvovirus B19, Human,
pubmed-meshheading:16415037-RNA, Viral,
pubmed-meshheading:16415037-RNA Precursors,
pubmed-meshheading:16415037-Sequence Homology, Nucleic Acid
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pubmed:year |
2006
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pubmed:articleTitle |
Identification and characterization of two internal cleavage and polyadenylation sites of parvovirus B19 RNA.
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pubmed:affiliation |
Department of Molecular Microbiology and Immunology, 471f Life Sciences Center, University of Missouri-Columbia, 1201 E. Rollins Rd., Columbia, MO 65211-7310, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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