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rdf:type |
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lifeskim:mentions |
umls-concept:C0003289,
umls-concept:C0015127,
umls-concept:C0205214,
umls-concept:C0205314,
umls-concept:C0205419,
umls-concept:C0358591,
umls-concept:C0679622,
umls-concept:C0683140,
umls-concept:C0683154,
umls-concept:C1314792,
umls-concept:C1332828,
umls-concept:C2347946
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pubmed:issue |
1
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pubmed:dateCreated |
2006-1-17
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pubmed:abstractText |
Many drugs, including proton pump inhibitors and certain antidepressants, are metabolized by the polymorphic cytochrome P450 (CYP) 2C19 enzyme. A significant portion of extensive metabolizers do not reach appropriate drug levels, and our objective was to investigate any genetic background.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0009-9236
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
103-13
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16413245-Animals,
pubmed-meshheading:16413245-Anticonvulsants,
pubmed-meshheading:16413245-Antidepressive Agents,
pubmed-meshheading:16413245-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:16413245-China,
pubmed-meshheading:16413245-Electrophoretic Mobility Shift Assay,
pubmed-meshheading:16413245-Enzyme Inhibitors,
pubmed-meshheading:16413245-Ethiopia,
pubmed-meshheading:16413245-Gene Frequency,
pubmed-meshheading:16413245-Genes, Reporter,
pubmed-meshheading:16413245-Genetic Variation,
pubmed-meshheading:16413245-Genotype,
pubmed-meshheading:16413245-Humans,
pubmed-meshheading:16413245-Male,
pubmed-meshheading:16413245-Mephenytoin,
pubmed-meshheading:16413245-Mice,
pubmed-meshheading:16413245-Mixed Function Oxygenases,
pubmed-meshheading:16413245-Mutation,
pubmed-meshheading:16413245-Omeprazole,
pubmed-meshheading:16413245-Phenotype,
pubmed-meshheading:16413245-Plasmids,
pubmed-meshheading:16413245-Proton Pumps,
pubmed-meshheading:16413245-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16413245-Sweden,
pubmed-meshheading:16413245-Transfection
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pubmed:year |
2006
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pubmed:articleTitle |
A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants.
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pubmed:affiliation |
Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm. Sarah.Sim@ki.se
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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