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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-3-27
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pubmed:databankReference |
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pubmed:abstractText |
We report the cloning and sequence analysis of Cerastes vipera and Macrovipera lebetina transmediterranea cDNAs coding for short non-RGD (Arg-Gly-Asp) disintegrins and for dimeric disintegrin subunits. The mRNAs belong to the short-coding class, suggesting that these disintegrin mRNAs may be more widely distributed than previously thought. Our data also argue for a common ancestry of the mRNAs of short disintegrins and those coding for precursors of dimeric disintegrin chains. The Macrovipera lebetina transmediterranea dimeric disintegrin reported to inhibit the laminin-binding integrins alpha3beta1, alpha6beta1 and alpha7beta1 was analysed using a proteomic approach and was shown to bear MLD (Met-Leu-Asp) and VGD (Val-Gly-Asp) motifs. The results highlight the fact that disintegrins have evolved a restricted panel of integrin-blocking sequences that segregate with defined branches of the phylogenetic tree of the integrin alpha-chains, providing novel insights into the evolutionary adaptation of the snake venom antagonists to the ligand-binding sites of their target integrin receptors.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16411889-10642516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16411889-11139295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16411889-11343790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16411889-11884718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16411889-12297042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16411889-12450389,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16411889-12667142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16411889-12719418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16411889-12727812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16411889-12742023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16411889-12833509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16411889-12947085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16411889-14557069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16411889-14760702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16411889-15014162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16411889-15276202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16411889-1529462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16411889-15317139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16411889-15556632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16411889-15581677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16411889-15741511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16411889-15777237,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16411889-16200076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16411889-16206329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16411889-16215260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16411889-8694817,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16411889-9839663
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1470-8728
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
395
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
385-92
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16411889-Amino Acid Sequence,
pubmed-meshheading:16411889-Animals,
pubmed-meshheading:16411889-Base Sequence,
pubmed-meshheading:16411889-Cloning, Molecular,
pubmed-meshheading:16411889-DNA, Complementary,
pubmed-meshheading:16411889-Dimerization,
pubmed-meshheading:16411889-Disintegrins,
pubmed-meshheading:16411889-Evolution, Molecular,
pubmed-meshheading:16411889-Gene Library,
pubmed-meshheading:16411889-Integrins,
pubmed-meshheading:16411889-Molecular Sequence Data,
pubmed-meshheading:16411889-Oligopeptides,
pubmed-meshheading:16411889-Sequence Alignment,
pubmed-meshheading:16411889-Spectrum Analysis,
pubmed-meshheading:16411889-Viper Venoms,
pubmed-meshheading:16411889-Viperidae
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pubmed:year |
2006
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pubmed:articleTitle |
Molecular cloning of disintegrins from Cerastes vipera and Macrovipera lebetina transmediterranea venom gland cDNA libraries: insight into the evolution of the snake venom integrin-inhibition system.
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pubmed:affiliation |
Instituto de Biomedicina de Valencia, C.S.I.C., Jaume Roig 11, 46010 Valencia, Spain.
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