Source:http://linkedlifedata.com/resource/pubmed/id/16411196
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2006-3-7
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| pubmed:abstractText |
It is not known whether C-fiber functional subclasses are differentially affected by diabetes mellitus or whether the patterns of C-fiber dysfunction are different between type 1 and type 2 diabetes. We therefore examined efferent sympathetic sudomotor and primary afferent nociceptor C-fiber function in diabetic patients. Acetylcholine (10%) was used to evoke C-fiber (axon-reflex)-mediated responses. The nociceptor (flare) response was measured using a laser Doppler device. The sudomotor response was quantified with silastic imprints. The nociceptor C-fiber-mediated flare response was reduced in type 2 diabetic patients (P < 0.008) but was similar to controls in type 1 diabetic patients. The sympathetic C-fiber-mediated responses, including sweat volume (P < 0.05) and the number of activated sweat glands (P = 0.003), were increased in patients with type 1 diabetes. There also was a trend toward a larger axon-reflex sweat area in patients with type 1 diabetes (P = 0.09). No differences in these sweat responses were found in patients with type 2 diabetes compared to controls. These findings suggest that the functional abnormalities in diabetic peripheral neuropathy are not homogeneous and that C-fiber subclasses are differentially affected in type 1 and 2 diabetes mellitus.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
0148-639X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
33
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
494-9
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| pubmed:meshHeading |
pubmed-meshheading:16411196-Acetylcholine,
pubmed-meshheading:16411196-Adult,
pubmed-meshheading:16411196-Axons,
pubmed-meshheading:16411196-Data Interpretation, Statistical,
pubmed-meshheading:16411196-Diabetes Mellitus, Type 1,
pubmed-meshheading:16411196-Diabetes Mellitus, Type 2,
pubmed-meshheading:16411196-Diabetic Nephropathies,
pubmed-meshheading:16411196-Female,
pubmed-meshheading:16411196-Forearm,
pubmed-meshheading:16411196-Humans,
pubmed-meshheading:16411196-Iontophoresis,
pubmed-meshheading:16411196-Male,
pubmed-meshheading:16411196-Middle Aged,
pubmed-meshheading:16411196-Nerve Fibers, Unmyelinated,
pubmed-meshheading:16411196-Nociceptors,
pubmed-meshheading:16411196-Reflex,
pubmed-meshheading:16411196-Regional Blood Flow,
pubmed-meshheading:16411196-Skin,
pubmed-meshheading:16411196-Sweating,
pubmed-meshheading:16411196-Sympathetic Nervous System,
pubmed-meshheading:16411196-Vasodilation,
pubmed-meshheading:16411196-Vasodilator Agents
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| pubmed:year |
2006
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| pubmed:articleTitle |
Differential impairment of the sudomotor and nociceptor axon-reflex in diabetic peripheral neuropathy.
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| pubmed:affiliation |
Department of Neurology, University of Münster, Münster, Germany.
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| pubmed:publicationType |
Journal Article
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