Source:http://linkedlifedata.com/resource/pubmed/id/16410698
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2006-1-13
|
| pubmed:abstractText |
Oxaliplatin (L-OHP) was administered to 10 patients previously treated for refractory advanced or recurrent colorectal cancer. The number of times each had received previous chemotherapy treatment ranged from 1 to 5 (median 3) for durations of 2.5 to 52.8 (median 11.7) months. At the time, L-OHP was not yet approved for sale in Japan, and could only be imported from overseas for personal use. As this made it very expensive,we used a low L-OHP dose of 100 mg/body. Combinations with 5-FU were administered differently from previous regimens; these included chronotherapy, weekly high-dose, FOLFOX 4, and FOLFOX 6. L-OHP was administered from 1 to 14 times (median 4.5), and the response to treatment was PR in 2 patients and NC in 5. The response rate was 22.2%. Although in NC there was a tendency toward tumor reduction in 2 of the 5 patients, the treatment had to be suspended because of their financial situations. Overall survival from commencement of the first treatment was 3.1 to 58.7 months (median 17.6+) and after starting L-OHP was 0.6 to 17.2 months (median 6.4+). Adverse events included bone marrow suppression in three patients, 3 cases of leukocytopenia (grade 3 in two patients and grade 4 in one), grade 4 thrombocytopenia in one patient,grade 3 sensory disturbance in one patient,and grade 3 anorexia in two patients. All reactions were able to be controlled except for one patient with Grade 4 thrombocytopenia. In summary,treatment with L-OHP as salvage chemotherapy can possibly contribute to prolongation of survival time in cases of refractory advanced colorectal cancer. It is useful to combine L-OHP with high-dose continuous administration of 5-FU,namely FOLFOX regimens.FOLFOX 6 is the most useful of the FOLFOX regimens because it is simple and can be administered on an outpatient basis.
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| pubmed:language |
jpn
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0385-0684
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
33
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
49-54
|
| pubmed:dateRevised |
2009-11-3
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| pubmed:meshHeading |
pubmed-meshheading:16410698-Aged,
pubmed-meshheading:16410698-Anorexia,
pubmed-meshheading:16410698-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:16410698-Colorectal Neoplasms,
pubmed-meshheading:16410698-Drug Administration Schedule,
pubmed-meshheading:16410698-Female,
pubmed-meshheading:16410698-Fluorouracil,
pubmed-meshheading:16410698-Humans,
pubmed-meshheading:16410698-Leucovorin,
pubmed-meshheading:16410698-Leukopenia,
pubmed-meshheading:16410698-Liver Neoplasms,
pubmed-meshheading:16410698-Lung Neoplasms,
pubmed-meshheading:16410698-Male,
pubmed-meshheading:16410698-Maximum Tolerated Dose,
pubmed-meshheading:16410698-Middle Aged,
pubmed-meshheading:16410698-Organoplatinum Compounds,
pubmed-meshheading:16410698-Salvage Therapy,
pubmed-meshheading:16410698-Thrombocytopenia
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
[Clinical administration of oxaliplatin for patients previously treated for refractory advanced or recurrent colorectal cancer].
|
| pubmed:affiliation |
Center for Digestive Diseases, Dept.of Medical Oncology, Tonan Hospital.
|
| pubmed:publicationType |
Journal Article,
English Abstract
|