| pubmed-article:16410613 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16410613 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:16410613 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:16410613 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:16410613 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:16410613 | lifeskim:mentions | umls-concept:C0205360 | lld:lifeskim |
| pubmed-article:16410613 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:16410613 | lifeskim:mentions | umls-concept:C0451119 | lld:lifeskim |
| pubmed-article:16410613 | lifeskim:mentions | umls-concept:C1444662 | lld:lifeskim |
| pubmed-article:16410613 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:16410613 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16410613 | pubmed:dateCreated | 2006-1-13 | lld:pubmed |
| pubmed-article:16410613 | pubmed:abstractText | RNA loop-loop interactions are a prevalent motif in the formation of tertiary structure and are well suited to trigger molecular recognition between RNA molecules. We determined the stabilities of several loop-loop interactions with a constant 6 bp core sequence and varying unpaired flanking nucleotides and found that the flanking bases have a strong influence on the stability and ion dependence of the kissing complex. In general, the stabilities determined in 1 M Na+ are equivalent to those in the presence of near physiological Mg2+ concentrations. Therefore we further tested whether the stabilities determined in vitro and within yeast cells correlate, using a recently developed yeast RNA-hybrid system. For the majority of the loop types analyzed here, the melting temperatures determined in vitro are in good agreement with the relative beta-galactosidase activity in yeast cells, showing that data derived from in vitro measurements reflect in vivo properties. The most stable interactions are the naturally occurring HIV-1 DIS MAL and LAI derived loops with the motif (5' A(A)/(G)N6A 3'), emphasizing the crucial role of stable kissing complexes in HIV genome dimerization. | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16410613 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16410613 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16410613 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16410613 | pubmed:issn | 1362-4962 | lld:pubmed |
| pubmed-article:16410613 | pubmed:author | pubmed-author:SchroederRené... | lld:pubmed |
| pubmed-article:16410613 | pubmed:author | pubmed-author:PiganeauNicol... | lld:pubmed |
| pubmed-article:16410613 | pubmed:author | pubmed-author:LorenzChristi... | lld:pubmed |
| pubmed-article:16410613 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:16410613 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:16410613 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16410613 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16410613 | pubmed:pagination | 334-42 | lld:pubmed |
| pubmed-article:16410613 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:16410613 | pubmed:meshHeading | pubmed-meshheading:16410613... | lld:pubmed |
| pubmed-article:16410613 | pubmed:meshHeading | pubmed-meshheading:16410613... | lld:pubmed |
| pubmed-article:16410613 | pubmed:meshHeading | pubmed-meshheading:16410613... | lld:pubmed |
| pubmed-article:16410613 | pubmed:meshHeading | pubmed-meshheading:16410613... | lld:pubmed |
| pubmed-article:16410613 | pubmed:meshHeading | pubmed-meshheading:16410613... | lld:pubmed |
| pubmed-article:16410613 | pubmed:meshHeading | pubmed-meshheading:16410613... | lld:pubmed |
| pubmed-article:16410613 | pubmed:meshHeading | pubmed-meshheading:16410613... | lld:pubmed |
| pubmed-article:16410613 | pubmed:meshHeading | pubmed-meshheading:16410613... | lld:pubmed |
| pubmed-article:16410613 | pubmed:meshHeading | pubmed-meshheading:16410613... | lld:pubmed |
| pubmed-article:16410613 | pubmed:meshHeading | pubmed-meshheading:16410613... | lld:pubmed |
| pubmed-article:16410613 | pubmed:meshHeading | pubmed-meshheading:16410613... | lld:pubmed |
| pubmed-article:16410613 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16410613 | pubmed:articleTitle | Stabilities of HIV-1 DIS type RNA loop-loop interactions in vitro and in vivo. | lld:pubmed |
| pubmed-article:16410613 | pubmed:affiliation | Max F. Perutz Laboratories, Department of Biochemistry, University of Vienna, Dr Bohrgasse 9/5, A-1030 Vienna, Austria. | lld:pubmed |
| pubmed-article:16410613 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16410613 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16410613 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16410613 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16410613 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16410613 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16410613 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16410613 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16410613 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16410613 | lld:pubmed |
