Source:http://linkedlifedata.com/resource/pubmed/id/16409423
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0001554,
umls-concept:C0017168,
umls-concept:C0017319,
umls-concept:C0030705,
umls-concept:C0033522,
umls-concept:C0034380,
umls-concept:C0034665,
umls-concept:C0087111,
umls-concept:C0337812,
umls-concept:C0443252,
umls-concept:C0542559,
umls-concept:C0679199,
umls-concept:C0937846,
umls-concept:C1273870,
umls-concept:C1280500,
umls-concept:C1457887
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| pubmed:issue |
1
|
| pubmed:dateCreated |
2006-1-13
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| pubmed:abstractText |
This article reports quality of life (QoL) aspects of a study that investigated the efficacy of three treatment regimens in gastro-oesophageal reflux disease patients. Following a 4-week symptom-control phase (esomeprazole 40 mg once daily), patients were randomised to 6 months' esomeprazole 20 mg once daily continuously (n = 658), on-demand (n = 634) or ranitidine 150 mg twice daily continuously (n = 610). Esomeprazole 40 mg once daily improved QoL during the symptom-control phase. At 6 months, both esomeprazole regimens were more effective than ranitidine in all dimensions of the Quality of Life in Reflux and Dyspepsia questionnaire (p < 0.0001). Esomeprazole continuous and on-demand led to a significant improvement in symptoms (Overall Treatment Evaluation questionnaire) compared with ranitidine (continuous: 80.2%, on-demand: 77.8%, vs. ranitidine 47.0%; p < 0.001). Esomeprazole once daily continuously maintained QoL better than esomeprazole on-demand and was associated with greater patient satisfaction. In conclusion, esomeprazole 20 mg once daily continuously and on-demand were more effective than ranitidine continuously for maintaining QoL.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1368-5031
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
60
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
15-22
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| pubmed:dateRevised |
2007-2-14
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| pubmed:meshHeading |
pubmed-meshheading:16409423-Adolescent,
pubmed-meshheading:16409423-Adult,
pubmed-meshheading:16409423-Aged,
pubmed-meshheading:16409423-Aged, 80 and over,
pubmed-meshheading:16409423-Anti-Ulcer Agents,
pubmed-meshheading:16409423-Family Practice,
pubmed-meshheading:16409423-Female,
pubmed-meshheading:16409423-Gastroesophageal Reflux,
pubmed-meshheading:16409423-Humans,
pubmed-meshheading:16409423-Male,
pubmed-meshheading:16409423-Middle Aged,
pubmed-meshheading:16409423-Omeprazole,
pubmed-meshheading:16409423-Patient Satisfaction,
pubmed-meshheading:16409423-Prospective Studies,
pubmed-meshheading:16409423-Proton Pumps,
pubmed-meshheading:16409423-Quality of Life,
pubmed-meshheading:16409423-Ranitidine,
pubmed-meshheading:16409423-Treatment Outcome
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| pubmed:year |
2006
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| pubmed:articleTitle |
Long-term management of patients with symptoms of gastro-oesophageal reflux disease -- a Norwegian randomised prospective study comparing the effects of esomeprazole and ranitidine treatment strategies on health-related quality of life in a general practitioners setting.
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| pubmed:affiliation |
Harbitzallèen Legesenter, Oslo, Norway. admin@oppsupport.com
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Randomized Controlled Trial,
Multicenter Study
|