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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2006-1-13
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pubmed:abstractText |
Alpha-thalassaemia caused by alpha-globin gene termination codon mutations (alphaT-globin) has been explained by their inherent mRNA instability and by oxidative damage arising from the presence of membrane-bound alphaT-globin chains. To better understand the latter phenomenon, a yeast two-hybrid system was used to assay the interaction between alphaT-globin and its molecular chaperone, alpha-haemoglobin-stabilising protein (AHSP) and impaired binding of alphaT-globin with AHSP compared with alpha(wild-type)-globin was observed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0007-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
132
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
370-3
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16409302-Blood Proteins,
pubmed-meshheading:16409302-Cloning, Molecular,
pubmed-meshheading:16409302-Gene Expression,
pubmed-meshheading:16409302-Globins,
pubmed-meshheading:16409302-Humans,
pubmed-meshheading:16409302-Molecular Chaperones,
pubmed-meshheading:16409302-Mutation,
pubmed-meshheading:16409302-Phenotype,
pubmed-meshheading:16409302-Protein Binding,
pubmed-meshheading:16409302-RNA, Messenger,
pubmed-meshheading:16409302-Saccharomyces cerevisiae,
pubmed-meshheading:16409302-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:16409302-alpha-Thalassemia
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pubmed:year |
2006
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pubmed:articleTitle |
Impaired interaction of alpha-haemoglobin-stabilising protein with alpha-globin termination mutant in a yeast two-hybrid system.
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pubmed:affiliation |
Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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