Linked Life Data

16406617

Source:http://linkedlifedata.com/resource/pubmed/id/16406617

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-2-20
pubmed:abstractText
The nuclear envelope has traditionally been thought of as a barrier that separates the nucleoplasm from the cytoplasm in eukaryotic cells. Increasing evidence shows that the nuclear envelope also links the inside of the nucleus to the cytoskeleton. Here we discuss recent papers showing that this link occurs through complexes of lamins on the inner aspect of the inner nuclear membrane, transmembrane proteins of the inner nuclear membrane called SUNs and large nesprin isoforms localized specifically to the outer nuclear membrane. These discoveries have implications for nuclear positioning, nuclear migration and pathogenesis of inherited diseases that are caused by mutations in nuclear envelope proteins.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0962-8924
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
67-9
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Here come the SUNs: a nucleocytoskeletal missing link.
pubmed:affiliation
Department of Anatomy and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. hjw14@columbia.edu
pubmed:publicationType
Journal Article