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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2006-11-3
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pubmed:abstractText |
In hemolytic diseases such as sickle cell disease and beta-thalassemia, the mechanisms of thrombosis are poorly understood, however erythrocyte/endothelium interactions are thought to play an important role. Appropriate animal models would increase our understanding of the pathophysiology of thrombosis and aid in the development of new therapeutic strategies. We previously reported that rats exposed to 2-butoxyethanol (2-BE) develop hemolysis and enhanced adherence of erythrocytes to the extracellular matrix, possibly secondary to the recruitment of cellular adhesion molecules at the erythrocyte/endothelium interface.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0049-3848
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
118
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
747-53
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pubmed:meshHeading |
pubmed-meshheading:16405975-Anemia, Hemolytic,
pubmed-meshheading:16405975-Anemia, Sickle Cell,
pubmed-meshheading:16405975-Animals,
pubmed-meshheading:16405975-Antithrombin III,
pubmed-meshheading:16405975-Biological Markers,
pubmed-meshheading:16405975-Cell Communication,
pubmed-meshheading:16405975-Disease Models, Animal,
pubmed-meshheading:16405975-Endothelium, Vascular,
pubmed-meshheading:16405975-Erythrocyte Aggregation,
pubmed-meshheading:16405975-Ethylene Glycols,
pubmed-meshheading:16405975-Female,
pubmed-meshheading:16405975-Hemolysis,
pubmed-meshheading:16405975-Hemostasis,
pubmed-meshheading:16405975-Intercellular Adhesion Molecule-1,
pubmed-meshheading:16405975-Peptide Hydrolases,
pubmed-meshheading:16405975-Rats,
pubmed-meshheading:16405975-Rats, Inbred F344,
pubmed-meshheading:16405975-Thrombosis,
pubmed-meshheading:16405975-beta-Thalassemia
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pubmed:year |
2006
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pubmed:articleTitle |
Hemostatic activation in a chemically induced rat model of severe hemolysis and thrombosis.
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pubmed:affiliation |
Hemostasis and Thrombosis Center, Department of Medicine, Duke University Medical Center, Duke University Health System, Box 3422 Durham, NC 27710, USA. Lewis064@mc.duke.edu
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pubmed:publicationType |
Journal Article
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