Linked Life Data

16400463

Source:http://linkedlifedata.com/resource/pubmed/id/16400463

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-1-9
pubmed:abstractText
We conducted a retrospective analysis of the influence of full doses of calcineurin inhibitors [8-10 mg kg-1 day-1 cyclosporine (N = 80), or 0.2-0.3 mg kg-1 day-1 tacrolimus (N = 68)] administered from day 1 after transplantation on the transplant outcomes of a high-risk population. Induction therapy was used in 13% of the patients. Patients also received azathioprine (2 mg kg(-1) day(-1), N = 58) or mycophenolate mofetil (2 g/day, N = 90), and prednisone (0.5 mg kg(-1) day(-1), N = 148). Mean time on dialysis was 79 +/- 41 months, 12% of the cases were re-transplants, and 21% had panel reactive antibodies > 10%. In 43% of donors the cause of death was cerebrovascular disease and 27% showed creatinine above 1.5 mg/dL. The incidence of slow graft function (SGF) and delayed graft function (DGF) was 15 and 60%, respectively. Mean time to last dialysis and to nadir creatinine were 18 +/- 15 and 34 +/- 20 days, respectively. Mean creatinine at 1 year after transplantation was 1.48 +/- 0.50 mg/dL (DGF 1.68 +/- 0.65 vs SGF 1.67 +/- 0.66 vs immediate graft function (IGF) 1.41 +/- 0.40 mg/dL, P = 0.089). The incidence of biopsy-confirmed acute rejection was 22% (DGF 31%, SGF 10%, IGF 8%). One-year patient and graft survival was 92.6 and 78.4%, respectively. The incidence of cytomegalovirus disease, post-transplant diabetes mellitus and malignancies was 28, 8.1, and 0%, respectively. Compared to previous studies, the use of initial full doses of calcineurin inhibitors without antibody induction in patients with SGF or DGF had no negative impact on patient and graft survival.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0100-879X
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
43-52
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:16400463-Adult, pubmed-meshheading:16400463-Azathioprine, pubmed-meshheading:16400463-Biopsy, pubmed-meshheading:16400463-Calcineurin, pubmed-meshheading:16400463-Creatinine, pubmed-meshheading:16400463-Cyclosporine, pubmed-meshheading:16400463-Delayed Graft Function, pubmed-meshheading:16400463-Drug Administration Schedule, pubmed-meshheading:16400463-Female, pubmed-meshheading:16400463-Graft Rejection, pubmed-meshheading:16400463-Humans, pubmed-meshheading:16400463-Immunosuppressive Agents, pubmed-meshheading:16400463-Kidney Transplantation, pubmed-meshheading:16400463-Male, pubmed-meshheading:16400463-Mycophenolic Acid, pubmed-meshheading:16400463-Prednisone, pubmed-meshheading:16400463-Retrospective Studies, pubmed-meshheading:16400463-Risk Factors, pubmed-meshheading:16400463-Severity of Illness Index, pubmed-meshheading:16400463-Tacrolimus, pubmed-meshheading:16400463-Treatment Outcome
pubmed:year
2006
pubmed:articleTitle
Impact of initial exposure to calcineurin inhibitors on kidney graft function of patients at high risk to develop delayed graft function.
pubmed:affiliation
Hospital do Rim e Hipertensão, Departamento de Patologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't