Linked Life Data

16399661

Source:http://linkedlifedata.com/resource/pubmed/id/16399661

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2006-1-9
pubmed:abstractText
Fine and ultrafine particles in ambient air are more consistently associated with severe adverse health effects than coarse particles. We assessed whether the effects of PM(2.5) on peak expiratory flow (PEF) and respiratory symptoms in asthma patients differ by the source or the chemical properties of particles. A panel of 57 adult asthmatics was followed for 181 days from November 1996 to April 1997 with 3 daily PEF measurements and diaries. Air quality, including elemental analyses of PM(2.5) filters every 2 days (n= 83), was monitored at a central site. Daily concentrations of PM(2.5) from different sources were estimated using principal component analysis and multiple linear regression. Associations of PM(2.5) from different sources with respiratory endpoints were examined using a generalized least squares autoregressive model after adjustment for covariates. PM(2.5) attributable to local combustion was consistently negatively associated with all measurements of PEF. One interquartile increase (1.3 microg/m(3)) in 5-day average concentrations of PM(2.5) attributable to local combustion was associated with an average 1.14 L/min decline in evening PEF (95% CI: -1.95 to -0.33 L/min). We also observed that PM(2.5) attributable to long-range transport was positively, and soil-derived PM(2.5) negatively, associated with PEF. No consistent associations were observed between source-specific PM(2.5) and respiratory symptoms or between individual chemical elements and any respiratory endpoints. Our results suggest that the negative effects of PM(2.5) on PEF in adult asthmatics are mainly mediated by particles related to local combustion sources.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1091-7691
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
191-8
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Source-specific fine particles in urban air and respiratory function among adult asthmatics.
pubmed:affiliation
National Public Health Institute, Department of Environmental Health, Kuopio, Finland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't