Linked Life Data

16399362

Source:http://linkedlifedata.com/resource/pubmed/id/16399362

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2006-1-9
pubmed:abstractText
Many cell types are known to release glutathione (GSH) and glutathione disulfide (GSSG). Multidrug resistance proteins (Mrps) have been identified to be involved in these export processes. In the brain, astrocytes have key functions in GSH metabolism and in antioxidative defense. These cells release large amounts of GSH under unstressed conditions as well as GSSG during oxidative stress. This chapter describes experimental paradigms to analyze the release of the physiological Mrp substrates GSH and GSSG from cultured astrocytes. These assay systems can be used to screen for compounds that affect Mrp1-mediated export from astrocytes and therefore could interfere with the antioxidative defense system of the brain. In addition, our methods could be useful in investigating mechanisms of export of GSH and GSSG from other cell types.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0076-6879
pubmed:author
pubmed:issnType
Print
pubmed:volume
400
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
395-409
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Multidrug resistance protein 1-mediated export of glutathione and glutathione disulfide from brain astrocytes.
pubmed:affiliation
Max-Planck Institute for Experimental Medicine, Department of Neurogenetics, Göttingen, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't