Linked Life Data

16397901

Source:http://linkedlifedata.com/resource/pubmed/id/16397901

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2006-2-2
pubmed:abstractText
Diffusion tensor magnetic resonance imaging (DT-MRI) was applied for in vivo quantification of myelin loss and regeneration. A transgenic mouse line (Oligo-TTK) expressing a truncated form of the herpes simplex virus 1 thymidine kinase gene (hsv1-tk) in oligodendrocytes was studied along with two induced phenotypes of myelin pathology. Myelin loss and axonal abnormalities differentially affect values of DT-MRI parameters in the brain of transgenic mice. Changes in the anisotropy of the white matter were assessed by calculating and mapping the radial (D perpendicular) and axial (D parallel) water diffusion to axonal tracts and fractional anisotropy (FA). A significant increase in D perpendicular attributed to the lack of myelin was observed in all selected brain white matter tracts in dysmyelinated mice. Lower D parallel values were consistent with the histological observation of axonal modifications, including reduced axonal caliber and overexpression of neurofilaments and III beta-tubulin. We show clearly that myelination and axonal changes play a role in the degree of diffusion anisotropy, because FA was significantly decreased in dysmyelinated brain. Importantly, myelin reparation during brain postnatal development induced a decrease in the magnitude of D( perpendicular) and an increase in FA compared with the same brain before recovery. The progressive increase in D parallel values was attributed to the gain in normal axonal morphology. This regeneration was confirmed by the detection of enlarged oligodendrocyte population, newly formed myelin sheaths around additional axons, and a gradual increase in axonal caliber.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0360-4012
pubmed:author
pubmed:copyrightInfo
Copyright 2006 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
392-402
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:16397901-Animals, pubmed-meshheading:16397901-Animals, Newborn, pubmed-meshheading:16397901-Anisotropy, pubmed-meshheading:16397901-Antiviral Agents, pubmed-meshheading:16397901-Brain, pubmed-meshheading:16397901-Brain Diseases, pubmed-meshheading:16397901-Brain Mapping, pubmed-meshheading:16397901-Demyelinating Diseases, pubmed-meshheading:16397901-Diffusion Magnetic Resonance Imaging, pubmed-meshheading:16397901-Ganciclovir, pubmed-meshheading:16397901-Image Processing, Computer-Assisted, pubmed-meshheading:16397901-Immunohistochemistry, pubmed-meshheading:16397901-Mice, pubmed-meshheading:16397901-Mice, Transgenic, pubmed-meshheading:16397901-Microscopy, Electron, Transmission, pubmed-meshheading:16397901-Myelin Basic Proteins, pubmed-meshheading:16397901-Nerve Fibers, Myelinated, pubmed-meshheading:16397901-Oligodendroglia, pubmed-meshheading:16397901-Protein-Serine-Threonine Kinases, pubmed-meshheading:16397901-Protein-Tyrosine Kinases, pubmed-meshheading:16397901-Recovery of Function, pubmed-meshheading:16397901-Time Factors
pubmed:year
2006
pubmed:articleTitle
Brain dysmyelination and recovery assessment by noninvasive in vivo diffusion tensor magnetic resonance imaging.
pubmed:affiliation
UMR 7004 CNRS/ULP, Institut de Physique Biologique, Faculté de Médecine,Université Louis Pasteur, Strasbourg, France.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't