Linked Life Data

16396929

Source:http://linkedlifedata.com/resource/pubmed/id/16396929

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 2
pubmed:dateCreated
2006-3-1
pubmed:abstractText
Glycinergic interplexiform cells provide a feedback signal from the inner retina to the outer retina. To determine if cones receive such a signal, glycine was applied on cultured porcine cone photoreceptors recorded with the patch clamp technique. A minor population of cone photoreceptors was found to generate large currents in response to puff application of glycine. These currents reversed close to the calculated equilibrium potential for chloride ions. These glycine-elicited currents were sensitive to strychnine but not to picrotoxin consistent with the expression of alpha-beta-heteromeric glycine receptors. Glycine receptors were also activated by taurine and beta-alanine. The glycine receptor antibody mAb4a labelled a minority of the cone photoreceptors identified by an antibody specific for cone arrestin. Finally, expression of the beta subunit of the glycine receptor was demonstrated by single cell RT-PCR in a similar proportion (approximately 13%) of cone photoreceptors freshly isolated by lectin-panning. The identity of cone photoreceptors was assessed by their specific expression of the cone arrestin mRNA. The population of cone photoreceptors expressing the glycine receptor was not correlated to a specific colour-sensitive subtype as demonstrated by single cell RT-PCR experiments using primers for S opsin, cone arrestin and glycine receptor beta subunit. This glycine receptor expression in a minority of cones defines a new cone population suggesting an unexpected role for glycine in the visual information processing in the outer retina.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-10367958, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-10396615, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-10482779, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-10530752, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-10733960, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-10750822, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-10762330, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-10865121, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-10939333, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-10995822, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-11437237, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-11487628, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-11588160, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-11920703, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-12115694, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-14614083, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-14998930, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-15046720, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-15180286, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-15623797, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-1693403, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-1703015, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-1720142, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-1760655, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-2163264, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-2172330, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-2176214, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-2341882, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-2871493, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-2982926, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-3037383, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-7623139, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-7754520, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-8046473, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-8088953, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-8227534, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-8603859, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-8604056, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-8843922, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-9131721, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-9349821, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-9395291, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-9665886, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-9667004, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-9667008, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-9782157, http://linkedlifedata.com/resource/pubmed/commentcorrection/16396929-9856773
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-3751
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
571
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
391-401
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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