rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
6
|
pubmed:dateCreated |
2006-1-10
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pubmed:abstractText |
Selective inhibitors of cyclo-oxygenase-2 (COX-2) appear to be safer than conventional NSAIDs on the gastrointestinal (GI) tract. Amtolmetin guacyl (AMG), a NSAID that inhibits both COX-1 and COX-2, has an anti-inflammatory effect comparable to that of traditional NSAIDs, with a better GI safety profile. The primary end-point of this study was to evaluate the gastrointestinal safety of amtolmetin guacyl in comparison with celecoxib in patients affected with rheumatoid arthritis. The assessment of efficacy was the secondary end-point.
|
pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:issn |
0392-856X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
23
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
809-18
|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16396699-Adult,
pubmed-meshheading:16396699-Aged,
pubmed-meshheading:16396699-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:16396699-Arthritis, Rheumatoid,
pubmed-meshheading:16396699-Cyclooxygenase Inhibitors,
pubmed-meshheading:16396699-Endoscopy, Digestive System,
pubmed-meshheading:16396699-Female,
pubmed-meshheading:16396699-Gastrointestinal Diseases,
pubmed-meshheading:16396699-Glycine,
pubmed-meshheading:16396699-Humans,
pubmed-meshheading:16396699-Male,
pubmed-meshheading:16396699-Middle Aged,
pubmed-meshheading:16396699-Pyrazoles,
pubmed-meshheading:16396699-Pyrroles,
pubmed-meshheading:16396699-Sulfonamides
|
pubmed:articleTitle |
Gastrointestinal safety of amtolmetin guacyl in comparison with celecoxib in patients with rheumatoid arthritis.
|
pubmed:affiliation |
Department for Rheumatology, Physical Medicine and Rehabilitation, Medical Faculty University of Zagreb, Referral Centre for Inflammatory Rheumatic Disease, Zagreb, Croatia. zjajic@mef.hr
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pubmed:publicationType |
Journal Article,
Comparative Study,
Randomized Controlled Trial,
Multicenter Study
|