Linked Life Data

16396629

Source:http://linkedlifedata.com/resource/pubmed/id/16396629

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2006-3-10
pubmed:abstractText
Brachial artery FMD (flow-mediated dilatation) is widely used as a marker of systemic arterial endothelial function. FMD, however, shows considerable 25% day-to-day variation that hinders its clinical use. The reasons for this variability are poorly characterized. Therefore the present study was designed to clarify factors responsible for the hourly variation in endothelial function, including consuming a low-fat meal and circadian rhythms in endogenous hormonal levels. Brachial artery FMD, along with serum glucose, triacylglycerols (triglycerides) and levels of several hormones were measured six times per day on two separate days 1 week apart. On one day, the subjects (healthy males: n=12, mean age, 24 years) ate a light breakfast and a standardized lunch (23.5% fat, 48.7% carbohydrate and 27.8% protein). On the other day, they had a similar breakfast after which they fasted. Postprandial FMD values (both after breakfast and after lunch) were similar to baseline FMD. FMD showed a 28% hourly variation and 27% weekly variation. Variation in plasma levels of insulin (P=0.02) associated negatively and DHPG (3,4-dihydroxyphenylglycol) (P=0.001), a marker of sympathetic nervous activation, associated positively with variation in FMD. The effects of DHPG and insulin on FMD were independent of changes in baseline brachial artery diameter, although DHPG was also inversely associated with baseline diameter. Eating a regular low-fat meal does not have any measurable effects on brachial artery endothelial function. These data suggest that strict requirements for fasting conditions may be unnecessary when measuring peripheral endothelial function using the ultrasound technique. Circadian variation in serum insulin and sympathetic tone are physiological determinants of endothelial function.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0143-5221
pubmed:author
pubmed:issnType
Print
pubmed:volume
110
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
475-82
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:16396629-Adult, pubmed-meshheading:16396629-Biological Markers, pubmed-meshheading:16396629-Blood Glucose, pubmed-meshheading:16396629-Brachial Artery, pubmed-meshheading:16396629-Catecholamines, pubmed-meshheading:16396629-Cholesterol, pubmed-meshheading:16396629-Circadian Rhythm, pubmed-meshheading:16396629-Endothelium, Vascular, pubmed-meshheading:16396629-Growth Hormone, pubmed-meshheading:16396629-Humans, pubmed-meshheading:16396629-Hydrocortisone, pubmed-meshheading:16396629-Insulin, pubmed-meshheading:16396629-Linear Models, pubmed-meshheading:16396629-Male, pubmed-meshheading:16396629-Methoxyhydroxyphenylglycol, pubmed-meshheading:16396629-Postprandial Period, pubmed-meshheading:16396629-Regional Blood Flow, pubmed-meshheading:16396629-Triglycerides, pubmed-meshheading:16396629-Vasodilation
pubmed:year
2006
pubmed:articleTitle
Determinants of short-term variation in arterial flow-mediated dilatation in healthy young men.
pubmed:affiliation
Department of Clinical Physiology, Turku University Central Hospital, University of Turku, Turku, Finland. mikko.jarvisalo@utu.fi
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, Non-U.S. Gov't