Linked Life Data

16395602

Source:http://linkedlifedata.com/resource/pubmed/id/16395602

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2006-2-17
pubmed:abstractText
Many human diseases result from the (partial) loss of gene function. Once a disease-causing gene has been identified, a wide variety of techniques can be used to study its function, structure and expression. Many clues can be obtained from the comparison of RNA or proteins in tissues, cell extracts or cell lines at different physiological or developmental stages. Since the mouse genome is very similar to the human genome, expression data from mice are extremely valuable. Recently developed techniques to add genes to the mouse genome or to modify or inactivate genes form powerful tools to analyze gene function and expression. For a variety of human diseases these genetically modified mice are very informative model systems.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0931-041X
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
318-23
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Teaching molecular genetics: chapter 2-Transgenesis and gene targeting: mouse models to study gene function and expression.
pubmed:affiliation
Department of Human Genetics of the Center for Human and Clinical Genetics, Leiden University Medical Center, Sylvius Laboratory, The Netherlands.
pubmed:publicationType
Journal Article