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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-1-5
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pubmed:abstractText |
Toll-like receptor 4 (TLR4) is required for efficient recognition of bacterial infections. We investigated an association between 2 TLR4 mutations (Asp(299)Gly and Thr(399)Ile) and meningococcal disease in 197 patients and 214 healthy controls by allele-specific real time polymerase chain reaction and direct sequencing. Although the allele frequency was not higher in the overall patient population, a significantly higher frequency in the 40 patients younger than 12 months of age (P = 0.007) was observed. We conclude that TLR4 mutations represent a risk factor for meningococcal disease in this age group.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0891-3668
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pubmed:author |
pubmed-author:FaberJoergJ,
pubmed-author:FinnAdamA,
pubmed-author:GemmerChristinaC,
pubmed-author:HabermehlPirminP,
pubmed-author:KnufMarkusM,
pubmed-author:MannhalterChristineC,
pubmed-author:MeyerClaudius UCU,
pubmed-author:MurdochCraigC,
pubmed-author:RussoAlexandraA,
pubmed-author:SchmittHeinz-JHJ,
pubmed-author:ZabelBernhard UBU,
pubmed-author:ZenzWernerW,
pubmed-author:ZeppFredF
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
80-1
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16395111-Age Factors,
pubmed-meshheading:16395111-Alleles,
pubmed-meshheading:16395111-Amino Acid Substitution,
pubmed-meshheading:16395111-Child,
pubmed-meshheading:16395111-Child, Preschool,
pubmed-meshheading:16395111-DNA,
pubmed-meshheading:16395111-Europe,
pubmed-meshheading:16395111-Female,
pubmed-meshheading:16395111-Gene Frequency,
pubmed-meshheading:16395111-Genetic Predisposition to Disease,
pubmed-meshheading:16395111-Humans,
pubmed-meshheading:16395111-Infant,
pubmed-meshheading:16395111-Male,
pubmed-meshheading:16395111-Meningococcal Infections,
pubmed-meshheading:16395111-Mutation, Missense,
pubmed-meshheading:16395111-Polymerase Chain Reaction,
pubmed-meshheading:16395111-Sequence Analysis, DNA,
pubmed-meshheading:16395111-Toll-Like Receptor 4
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pubmed:year |
2006
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pubmed:articleTitle |
Human toll-like receptor 4 mutations are associated with susceptibility to invasive meningococcal disease in infancy.
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pubmed:affiliation |
Children's Hospital, Johannes Gutenberg-University, Mainz, Germany. faber@uni-mainz.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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