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pubmed-article:16393227pubmed:abstractTextA defect of gastrointestinal barrier function is considered to represent an important step in the pathogenesis of Crohn's disease (CD) but the mechanisms leading to an increased intestinal permeability (IP) are poorly understood. Since IP is influenced by pro-inflammatory mediators, it seems likely that a genetically determined abnormal immune response may lead to a loss of barrier function.lld:pubmed
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pubmed-article:16393227pubmed:articleTitleIntestinal permeability and genetic determinants in patients, first-degree relatives, and controls in a high-incidence area of Crohn's disease in Southern Italy.lld:pubmed
pubmed-article:16393227pubmed:affiliationDipartimento di Medicina Interna e Terapia Medica, Università di Messina, Messina, Italy.lld:pubmed
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