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rdf:type |
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lifeskim:mentions |
umls-concept:C0010346,
umls-concept:C0021853,
umls-concept:C0022277,
umls-concept:C0030705,
umls-concept:C0031164,
umls-concept:C0080103,
umls-concept:C0205146,
umls-concept:C0314603,
umls-concept:C1521761,
umls-concept:C1710133,
umls-concept:C2587213
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|
pubmed:issue |
12
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pubmed:dateCreated |
2006-1-5
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|
pubmed:abstractText |
A defect of gastrointestinal barrier function is considered to represent an important step in the pathogenesis of Crohn's disease (CD) but the mechanisms leading to an increased intestinal permeability (IP) are poorly understood. Since IP is influenced by pro-inflammatory mediators, it seems likely that a genetically determined abnormal immune response may lead to a loss of barrier function.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0002-9270
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pubmed:author |
pubmed-author:CottoneMarioM,
pubmed-author:FriesWalterW,
pubmed-author:GiofréMaria RMR,
pubmed-author:Lo PrestiMaria AMA,
pubmed-author:MacalusoAlfredoA,
pubmed-author:MaggioAurelioA,
pubmed-author:MattalianoAnnaA,
pubmed-author:OlivaLorenzoL,
pubmed-author:OrlandoAmbrogioA,
pubmed-author:RasoAntonellaA,
pubmed-author:RendaMaria CMC
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|
pubmed:issnType |
Print
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pubmed:volume |
100
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
2730-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16393227-Adult,
pubmed-meshheading:16393227-Capillary Permeability,
pubmed-meshheading:16393227-Case-Control Studies,
pubmed-meshheading:16393227-Cohort Studies,
pubmed-meshheading:16393227-Crohn Disease,
pubmed-meshheading:16393227-Endemic Diseases,
pubmed-meshheading:16393227-Female,
pubmed-meshheading:16393227-Genetic Predisposition to Disease,
pubmed-meshheading:16393227-Genetics, Population,
pubmed-meshheading:16393227-Humans,
pubmed-meshheading:16393227-Incidence,
pubmed-meshheading:16393227-Intestinal Mucosa,
pubmed-meshheading:16393227-Italy,
pubmed-meshheading:16393227-Male,
pubmed-meshheading:16393227-Middle Aged,
pubmed-meshheading:16393227-Mutation,
pubmed-meshheading:16393227-Pedigree,
pubmed-meshheading:16393227-Probability,
pubmed-meshheading:16393227-Reference Values,
pubmed-meshheading:16393227-Risk Assessment,
pubmed-meshheading:16393227-Statistics, Nonparametric,
pubmed-meshheading:16393227-Toll-Like Receptor 4
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pubmed:year |
2005
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pubmed:articleTitle |
Intestinal permeability and genetic determinants in patients, first-degree relatives, and controls in a high-incidence area of Crohn's disease in Southern Italy.
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pubmed:affiliation |
Dipartimento di Medicina Interna e Terapia Medica, Università di Messina, Messina, Italy.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
