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pubmed-article:16392026pubmed:abstractTextRaloxifene improves spine bone mineral density (BMD), and its ability to reduce vertebral fractures by 40-50% suggests that it increases vertebral strength. Positive effects on hip BMD suggest a similar strengthening of the hip, but dimensional ambiguities in BMD by dual energy x-ray absorptiometry (DXA) make it difficult to infer strength effects directly. Hip fractures may be too infrequent to evaluate in practical clinical trials; even the Multiple Outcomes of Raloxifene Evaluation (MORE) study with 7,705 subjects was insufficiently powered to show a comparable reduction in hip fractures.lld:pubmed
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pubmed-article:16392026pubmed:articleTitleStructural effects of raloxifene on the proximal femur: results from the multiple outcomes of raloxifene evaluation trial.lld:pubmed
pubmed-article:16392026pubmed:affiliationDepartment of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.lld:pubmed
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