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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-1-4
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pubmed:abstractText |
Gliomas treated with the alkylating agent temozolomide have incomplete responses in part because of tumoral repair of chemotherapy-induced DNA damage. Data from phase I trials suggest that G207, an oncolytic herpes simplex virus (HSV) with mutated ribonucleotide reductase (RR) and gamma34.5 genes, is safe but needs greater viral oncolysis to be effective. We hypothesized that temozolomide and G207 treatment limitations could be jointly addressed using temozolomide-induced tumor-protective DNA repair pathways to enhance viral replication.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Alkylating,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Dacarbazine,
http://linkedlifedata.com/resource/pubmed/chemical/Guanine,
http://linkedlifedata.com/resource/pubmed/chemical/O(6)-Methylguanine-DNA...,
http://linkedlifedata.com/resource/pubmed/chemical/O-(6)-methylguanine,
http://linkedlifedata.com/resource/pubmed/chemical/PPP1R15A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ppp1r15a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Phosphatase 1,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleotide Reductases,
http://linkedlifedata.com/resource/pubmed/chemical/temozolomide
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1460-2105
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
4
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pubmed:volume |
98
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
38-50
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16391370-Animals,
pubmed-meshheading:16391370-Antigens, Differentiation,
pubmed-meshheading:16391370-Antineoplastic Agents, Alkylating,
pubmed-meshheading:16391370-Cell Cycle Proteins,
pubmed-meshheading:16391370-Cell Line, Tumor,
pubmed-meshheading:16391370-Comet Assay,
pubmed-meshheading:16391370-DNA Damage,
pubmed-meshheading:16391370-DNA Repair,
pubmed-meshheading:16391370-Dacarbazine,
pubmed-meshheading:16391370-Drug Synergism,
pubmed-meshheading:16391370-Flow Cytometry,
pubmed-meshheading:16391370-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:16391370-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16391370-Glioblastoma,
pubmed-meshheading:16391370-Guanine,
pubmed-meshheading:16391370-Humans,
pubmed-meshheading:16391370-Mice,
pubmed-meshheading:16391370-Mice, Nude,
pubmed-meshheading:16391370-O(6)-Methylguanine-DNA Methyltransferase,
pubmed-meshheading:16391370-Oncolytic Viruses,
pubmed-meshheading:16391370-Plasmids,
pubmed-meshheading:16391370-Protein Phosphatase 1,
pubmed-meshheading:16391370-RNA, Small Interfering,
pubmed-meshheading:16391370-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16391370-Ribonucleotide Reductases,
pubmed-meshheading:16391370-Simplexvirus,
pubmed-meshheading:16391370-Transcription, Genetic,
pubmed-meshheading:16391370-Transfection,
pubmed-meshheading:16391370-Transplantation, Heterologous
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pubmed:year |
2006
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pubmed:articleTitle |
Effect of chemotherapy-induced DNA repair on oncolytic herpes simplex viral replication.
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pubmed:affiliation |
Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. maghi@partners.org
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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