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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1992-8-28
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pubmed:abstractText |
Mutants of the mec-7 beta-tubulin gene of Caenorhabditis elegans lack the large diameter 15-protofilament microtubules normally found only in the set of six touch receptor neurons. Both a mec-7-lacZ reporter gene and affinity-purified anti-mec-7 antibodies were used to show that mec-7 is expressed primarily in the touch neurons. These data are consistent with a possible instructive role for the mec-7 tubulin in determining microtubule protofilament number. The antibodies and the mec-7-lacZ transgene were also used to examine mec-7 expression in mutants affecting the generation, differentiation or maintenance of the touch neurons. Decreased expression was observed in mutants of unc-86 and mec-3, genes that encode transcription factors essential for touch receptor neuron generation and differentiation, respectively.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-11813735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-16453714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-1672038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-1684166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-17248881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-1935914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-1970117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-1970421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-2118141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-2121610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-2183840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-2257628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-2576011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-2646709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-2695144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-2744465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-2898300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-2903797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-2981859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-3058169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-3073909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-3200316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-4366476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-479300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-5432063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-6494891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-6819086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-7014288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-7068753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1639062-7227647
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:geneSymbol |
mec-7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2885-93
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pubmed:dateRevised |
2010-9-9
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pubmed:meshHeading |
pubmed-meshheading:1639062-Amino Acid Sequence,
pubmed-meshheading:1639062-Animals,
pubmed-meshheading:1639062-Animals, Genetically Modified,
pubmed-meshheading:1639062-Antibodies,
pubmed-meshheading:1639062-Blotting, Western,
pubmed-meshheading:1639062-Caenorhabditis,
pubmed-meshheading:1639062-Cloning, Molecular,
pubmed-meshheading:1639062-Genes,
pubmed-meshheading:1639062-Larva,
pubmed-meshheading:1639062-Molecular Sequence Data,
pubmed-meshheading:1639062-Neurons,
pubmed-meshheading:1639062-Peptides,
pubmed-meshheading:1639062-Promoter Regions, Genetic,
pubmed-meshheading:1639062-Recombinant Fusion Proteins,
pubmed-meshheading:1639062-Sensory Receptor Cells,
pubmed-meshheading:1639062-Touch,
pubmed-meshheading:1639062-Tubulin,
pubmed-meshheading:1639062-beta-Galactosidase
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pubmed:year |
1992
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pubmed:articleTitle |
The mec-7 beta-tubulin gene of Caenorhabditis elegans is expressed primarily in the touch receptor neurons.
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pubmed:affiliation |
Division of Molecular Immunology and Neurobiology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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