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pubmed:abstractText |
Tenofovir disoproxil fumarate, a prodrug of the nucleotide reverse transcriptase inhibitor, tenofovir (9-[9(R)-2-(phosphonomethoxy)propyl]adenine; PMPA), was recently approved for use in the combination therapy of human immunodeficiency virus (HIV)-1 infection. This study was undertaken to understand PMPA distribution to the virus sanctuary sites located in the brain, CSF and choroid plexuses and to clarify its possible role in reducing the neurological problems associated with HIV infection.
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pubmed:affiliation |
King's College London, Wolfson Centre for Age-related Diseases, Guy's Campus, Hodgkin Building, London SE1 1UL, UK. anthonypillai9@hotmail.com
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