rdf:type |
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lifeskim:mentions |
|
pubmed:issue |
4
|
pubmed:dateCreated |
2006-4-11
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pubmed:abstractText |
Direct injection of lentivectors into the central nervous system (CNS) mostly results in localized parenchymal transgene expression. Intrathecal gene delivery into the spinal canal may produce a wider dissemination of the transgene and allow diffusion of secreted transgenic proteins throughout the cerebrospinal fluid (CSF). Herein, we analyze the distribution and expression of LacZ and SEAP transgenes following the intrathecal delivery of lentivectors into the spinal canal.
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pubmed:grant |
|
pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
1099-498X
|
pubmed:author |
|
pubmed:copyrightInfo |
Copyright 2006 John Wiley & Sons, Ltd.
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pubmed:issnType |
Print
|
pubmed:volume |
8
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
414-24
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:16389638-Alkaline Phosphatase,
pubmed-meshheading:16389638-Animals,
pubmed-meshheading:16389638-Animals, Newborn,
pubmed-meshheading:16389638-Central Nervous System,
pubmed-meshheading:16389638-Gene Expression,
pubmed-meshheading:16389638-Genetic Vectors,
pubmed-meshheading:16389638-Injections, Spinal,
pubmed-meshheading:16389638-Lentivirus,
pubmed-meshheading:16389638-Mice,
pubmed-meshheading:16389638-Mice, Inbred BALB C,
pubmed-meshheading:16389638-Polymerase Chain Reaction,
pubmed-meshheading:16389638-Time Factors,
pubmed-meshheading:16389638-Transduction, Genetic,
pubmed-meshheading:16389638-beta-Galactosidase
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pubmed:year |
2006
|
pubmed:articleTitle |
Lentiviral gene delivery to CNS by spinal intrathecal administration to neonatal mice.
|
pubmed:affiliation |
Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.
|
pubmed:publicationType |
Journal Article,
Evaluation Studies,
Research Support, N.I.H., Extramural
|