16389198

Source:http://linkedlifedata.com/resource/pubmed/id/16389198

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0003595, umls-concept:C0017431, umls-concept:C0026969, umls-concept:C0237401, umls-concept:C0338656, umls-concept:C0497327, umls-concept:C0699900
pubmed:issue	1
pubmed:dateCreated	2006-1-3
pubmed:abstractText	Apolipoprotein E (APOE) genotype is the most influential Alzheimer disease (AD) risk factor after advanced age. The APOE4 alleles decrease and the APOE2 alleles increase age at onset of AD. Human and nonhuman primate data suggest that in midlife, the structural integrity of myelin sheaths begins breaking down, with an accelerating age-related trajectory most evident in the brain's later-myelinating association regions. This may result in a progressive "disconnection" of widely distributed neural networks that may underlie the age risk factor for AD.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/MH066029-01A2, http://linkedlifedata.com/resource/pubmed/grant/MH51928, http://linkedlifedata.com/resource/pubmed/grant/MH6357-01A1, http://linkedlifedata.com/resource/pubmed/grant/P50 AG 16570
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0372435
pubmed:citationSubset	AIM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins E
pubmed:status	MEDLINE
pubmed:month	Jan
pubmed:issn	0003-990X
pubmed:author	pubmed-author:BartzokisGeorgeG, pubmed-author:CummingsJeffrey LJL, pubmed-author:EdwardsNancyN, pubmed-author:GeschwindDaniel HDH, pubmed-author:MintzJimJ, pubmed-author:PohlMM
pubmed:issnType	Print
pubmed:volume	63
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	63-72
pubmed:dateRevised	2007-11-14
pubmed:meshHeading	pubmed-meshheading:16389198-Age Factors, pubmed-meshheading:16389198-Age of Onset, pubmed-meshheading:16389198-Aged, pubmed-meshheading:16389198-Alzheimer Disease, pubmed-meshheading:16389198-Apolipoproteins E, pubmed-meshheading:16389198-Cognition Disorders, pubmed-meshheading:16389198-Corpus Callosum, pubmed-meshheading:16389198-Cross-Sectional Studies, pubmed-meshheading:16389198-Disease Progression, pubmed-meshheading:16389198-Female, pubmed-meshheading:16389198-Frontal Lobe, pubmed-meshheading:16389198-Genetic Predisposition to Disease, pubmed-meshheading:16389198-Genotype, pubmed-meshheading:16389198-Humans, pubmed-meshheading:16389198-Magnetic Resonance Imaging, pubmed-meshheading:16389198-Male, pubmed-meshheading:16389198-Myelin Sheath, pubmed-meshheading:16389198-Primary Prevention, pubmed-meshheading:16389198-Prognosis
pubmed:year	2006
pubmed:articleTitle	Apolipoprotein E genotype and age-related myelin breakdown in healthy individuals: implications for cognitive decline and dementia.
pubmed:affiliation	Department of Neurology, The David Geffen School of Medicine at UCLA, USA. gbar@ucla.edu
pubmed:publicationType	Journal Article, Comparative Study, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural