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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-1-3
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pubmed:abstractText |
Women who are carrying a trisomy 13 fetus are more prone to develop preeclampsia. Excess circulating soluble fms-like tyrosine kinase-1 has been implicated recently in the pathogenesis of preeclampsia. Since the fms-like tyrosine kinase-1/soluble fms-like tyrosine kinase-1 gene is located on chromosome 13q12, we hypothesized that the extra copy of this gene in trisomy 13 may lead to excess circulating soluble fms-like tyrosine kinase-1, reduced free placental growth factor level, and increased soluble fms-like tyrosine kinase-1/placental growth factor ratio. This may then contribute to the increased risk of preeclampsia that has been observed in these patients. Our objective was to characterize the maternal circulating angiogenic proteins in trisomy 13 pregnancies.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1097-6868
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
194
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
239-45
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pubmed:dateRevised |
2009-11-25
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pubmed:meshHeading |
pubmed-meshheading:16389038-Angiogenic Proteins,
pubmed-meshheading:16389038-Case-Control Studies,
pubmed-meshheading:16389038-Chromosomes, Human, Pair 13,
pubmed-meshheading:16389038-Chromosomes, Human, Pair 18,
pubmed-meshheading:16389038-Down Syndrome,
pubmed-meshheading:16389038-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:16389038-Female,
pubmed-meshheading:16389038-Humans,
pubmed-meshheading:16389038-Pregnancy,
pubmed-meshheading:16389038-Pregnancy Proteins,
pubmed-meshheading:16389038-Pregnancy Trimester, First,
pubmed-meshheading:16389038-Pregnancy Trimester, Second,
pubmed-meshheading:16389038-Single-Blind Method,
pubmed-meshheading:16389038-Trisomy,
pubmed-meshheading:16389038-Vascular Endothelial Growth Factor Receptor-1
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pubmed:year |
2006
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pubmed:articleTitle |
Circulating angiogenic proteins in trisomy 13.
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pubmed:affiliation |
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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