Source:http://linkedlifedata.com/resource/pubmed/id/16387687
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
2006-1-2
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pubmed:abstractText |
Histamine is an important mediator of allergic responses. Arthropods express several biologically active proteins in their saliva, which may allow a prolonged blood meal on the host. Proteins identified and expressed include histamine, serotonin, tryptase, and complement binding proteins. We review here data that scavenging of endogenous histamine by the histamine-binding protein EV131 has a profound inhibitory effect on allergic asthma. Aerosol administration of EV131 prevented airway hyperreactivity and abrogated peribronchial inflammation, eosinophil recruitment, mucus hypersecretion, and IL-4 and IL-5 secretion. Saturation with histamine abrogated the inhibitory effect of EV131 on bronchial hyperreactivity. The data suggest that histamine plays a role in allergies and that scavenging of histamine by EV131 may represent a novel therapeutic strategy in the treatment of allergic diseases.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Asthmatic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Histamine H1 Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Histamine H2 Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0077-8923
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
1056
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
189-96
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pubmed:meshHeading |
pubmed-meshheading:16387687-Animals,
pubmed-meshheading:16387687-Anti-Asthmatic Agents,
pubmed-meshheading:16387687-Arthropods,
pubmed-meshheading:16387687-Carrier Proteins,
pubmed-meshheading:16387687-Histamine H1 Antagonists,
pubmed-meshheading:16387687-Histamine H2 Antagonists,
pubmed-meshheading:16387687-Humans,
pubmed-meshheading:16387687-Proteins
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pubmed:year |
2005
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pubmed:articleTitle |
Arthropod-derived protein EV131 inhibits histamine action and allergic asthma.
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pubmed:affiliation |
Evolutec Ltd., Reading, United Kingdom.
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pubmed:publicationType |
Journal Article
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