Linked Life Data

16387086

Source:http://linkedlifedata.com/resource/pubmed/id/16387086

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2006-1-2
pubmed:abstractText
The aim of the study was to analyze whether immunosuppressive treatment with basiliximab and mycophenolate mofetil (MMF), allowed a reduction in methylprednisolone and cyclosporine dosages without increasing the incidence of acute rejection episodes, reducing 1-year graft and patient survivals, or increasing the rates of infections and malignancy in the first year. The two groups were group A (n = 72), treated with methylprednisolone and cyclosporine and in the first 2 weeks with azathioprine; group B (n = 72), treated with basiliximab, MMF, and low-dose cyclosporine and methylprednisolone. The patients were followed for 1 year. The incidence of acute rejection episodes in the first year was significantly lower in group B (2.8%) than group A (12.5%; P < .05). The cumulative methylprednisolone dose, the daily dose, and the average cyclosporine trough blood level were significantly lower in group B (P < .001). One-year serum creatinine was significantly lower in group B (112 +/- 45 micromol/L) than group A (138 +/- 51 micromol/L; P < .01). One-year graft survival was 91.7% in group A and 98.6% in group B. One-year patient survival was 98.6% in group A and 100% in group B. The groups did not differ significantly in the incidence of bacterial, viral, or fungal infections. Immunosuppression with basiliximab and MMF allowed a reduction in cyclosporine and methylprednisolone dosages and was associated with significantly lower incidences of acute rejections episodes with better graft function in the first year as opposed to immunosuppression with higher doses of cyclosporine and methylprednisolone alone. Both immunosuppressive regimens showed the same infection rates and did not differ significantly in the occurrence of malignant diseases within the first year.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0041-1345
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4230-4
pubmed:meshHeading
pubmed-meshheading:16387086-Acute Disease, pubmed-meshheading:16387086-Adolescent, pubmed-meshheading:16387086-Adult, pubmed-meshheading:16387086-Aged, pubmed-meshheading:16387086-Antibodies, Monoclonal, pubmed-meshheading:16387086-Azathioprine, pubmed-meshheading:16387086-Cyclosporine, pubmed-meshheading:16387086-Drug Therapy, Combination, pubmed-meshheading:16387086-Female, pubmed-meshheading:16387086-Graft Rejection, pubmed-meshheading:16387086-Histocompatibility Testing, pubmed-meshheading:16387086-Humans, pubmed-meshheading:16387086-Immunosuppressive Agents, pubmed-meshheading:16387086-Kidney Transplantation, pubmed-meshheading:16387086-Male, pubmed-meshheading:16387086-Methylprednisolone, pubmed-meshheading:16387086-Middle Aged, pubmed-meshheading:16387086-Mycophenolic Acid, pubmed-meshheading:16387086-Recombinant Fusion Proteins, pubmed-meshheading:16387086-Reoperation, pubmed-meshheading:16387086-Retrospective Studies, pubmed-meshheading:16387086-Treatment Outcome
pubmed:year
2005
pubmed:articleTitle
Basiliximab and mycophenolate mofetil in combination with low-dose cyclosporine and methylprednisolone effectively prevent acute rejection in kidney transplant recipients.
pubmed:affiliation
Department of Nephrology, University Medical Centre, and Institute of Microbiology and Immunology, University of Ljubljana, Ljubljana, Slovenia. damjan.kovac@guest.arnes.si
pubmed:publicationType
Journal Article, Clinical Trial