Linked Life Data

16386222

Source:http://linkedlifedata.com/resource/pubmed/id/16386222

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-1-2
pubmed:abstractText
Upstream stimulating factors, USF-1 and -2, are members of the evolutionary conserved basic-Helix-Loop-Helix-Leucine Zipper transcription factor family. The ubiquitously expressed USF-1 and -2 proteins of respectively 43 kDa and 44 kDa interact with high affinity to cognate E-box regulatory elements (CANNTG) which are particularly represented over the genome. The USF transcription factors are key regulatory elements of the transcriptional machinery mediating recruitment of chromatin remodelling enzymes, interacting with co-activators and members of the pre-initiation complex (PIC). Furthermore, transcriptionnal activity and DNA-binding of the USF proteins can be modulated by multiple ways including phosphorylation by distinct kinases (p38, protein kinase A and C, cdk1 and PI3Kinase), homo or heterodimerization formation and DNA modification of the E-box binding motif (methylation, SNP). Taken together, these parameters render very complex the understanding of the USF-dependent gene expression regulation. USF transcription factors have thus been involved as key regulators of a wide number of gene regulation network including stress and immune response, cell cycle and proliferation. This review will thus focus on general aspect of the USF transcription factors and their implications in some regulatory networks.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0767-0974
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
62-7
pubmed:dateRevised
2007-4-13
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
[USF as a key regulatory element of gene expression].
pubmed:affiliation
CNRS UMR 6061, Laboratoire de génétique et développement, Faculté de Médecine, Université de Rennes 1, France.
pubmed:publicationType
Journal Article, English Abstract, Review