Human urate transporter 1 (hURAT1) is a member of the organic anion transporter family (SLC22A12) that mainly regulates tubular urate reabsorption. Loss-of-function mutations result in idiopathic hypouricemia. The present case-control study was designed to analyze whether hURAT1 might also be a candidate gene for hyperuricemia with primary reduced renal urate excretion.
Department of Pathological Biochemistry, Clinic of Internal Medicine III, Carl Gustav Carus Medical School, University of Technology-Dresden, Fetscherstrasse 74, D-01307 Dresden, Germany. Juergen.Graessler@mailbox.tu-dresden.de
