Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2005-12-29
pubmed:abstractText
Parkinson's disease (PD) is a chronic and progressive neurological disorder characterized by selective degeneration of dopaminergic neurons (DAergic) in the substantia nigra pars compacta (SNpc) and subsequent decrease in dopamine (DA) levels in the striatum. Although levodopa replacement therapy is initially effective in symptomatic treatment of parkinsonian patients, its effectiveness often declines and various levodopa-related side effects appear after long-term treatment. The disabling side effects of levodopa therapy include motor fluctuations such as the wearing-off or on-off phenomena, dyskinesias and psychiatric symptoms. Nowadays, DA receptor agonists are often regarded as first choice in de novo and young parkinsonian patients to delay the onset of levodopa therapy. In advanced stages of the disease, they are also used as adjunct therapy together with levodopa to retard the development of motor complications. DA receptor agonists mimic the endogenous neurotransmitter, dopamine, and act by direct stimulation of presynaptic (autoreceptors) and postsynaptic DA receptors. Next to their clinical role in treating parkinsonian patients, laboratory studies reported antioxidative and neuron-rescuing effects of DA receptor agonists either in vivo or in vitro. This may involve reduced DA turnover following autoreceptor stimulation and direct free radical scavenging activity. In this review, we focus on and summarize the recently reported effects of the most commonly used DA agonists either in clinical or in research studies relevant to PD treatment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants, http://linkedlifedata.com/resource/pubmed/chemical/Antiparkinson Agents, http://linkedlifedata.com/resource/pubmed/chemical/Benzothiazoles, http://linkedlifedata.com/resource/pubmed/chemical/Bromocriptine, http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Agonists, http://linkedlifedata.com/resource/pubmed/chemical/Free Radicals, http://linkedlifedata.com/resource/pubmed/chemical/Indoles, http://linkedlifedata.com/resource/pubmed/chemical/Levodopa, http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents, http://linkedlifedata.com/resource/pubmed/chemical/Pergolide, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine, http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles, http://linkedlifedata.com/resource/pubmed/chemical/pramipexol, http://linkedlifedata.com/resource/pubmed/chemical/ropinirole
pubmed:status
MEDLINE
pubmed:issn
1734-1140
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
701-12
pubmed:dateRevised
2008-5-28
pubmed:meshHeading
pubmed-meshheading:16382188-Animals, pubmed-meshheading:16382188-Antioxidants, pubmed-meshheading:16382188-Antiparkinson Agents, pubmed-meshheading:16382188-Benzothiazoles, pubmed-meshheading:16382188-Brain, pubmed-meshheading:16382188-Bromocriptine, pubmed-meshheading:16382188-Clinical Trials as Topic, pubmed-meshheading:16382188-Dopamine, pubmed-meshheading:16382188-Dopamine Agonists, pubmed-meshheading:16382188-Drug Evaluation, Preclinical, pubmed-meshheading:16382188-Free Radicals, pubmed-meshheading:16382188-Humans, pubmed-meshheading:16382188-Indoles, pubmed-meshheading:16382188-Levodopa, pubmed-meshheading:16382188-Neurons, pubmed-meshheading:16382188-Neuroprotective Agents, pubmed-meshheading:16382188-Parkinson Disease, pubmed-meshheading:16382188-Pergolide, pubmed-meshheading:16382188-Receptors, Dopamine, pubmed-meshheading:16382188-Thiazoles
pubmed:articleTitle
Short review on dopamine agonists: insight into clinical and research studies relevant to Parkinson's disease.
pubmed:affiliation
Institute for Medical Chemistry, Veterinary Medical University, Veterinaerplatz 1, A-1210, Vienna, Austria.
pubmed:publicationType
Journal Article, Review